Lee Hyeonah, Noh Hyeran
Department of Optometry, Seoul National University of Science and Technology, Gongnung-ro 232, Nowon-gu, Seoul 01811, Republic of Korea.
Gels. 2023 Sep 4;9(9):718. doi: 10.3390/gels9090718.
Nanomedicine in gel or particle formation holds considerable potential for enhancing passive and active targeting within ocular drug delivery systems. The complex barriers of the eye, exemplified by the intricate network of closely connected tissue structures, pose significant challenges for drug administration. Leveraging the capability of engineered nanomedicine offers a promising approach to enhance drug penetration, particularly through active targeting agents such as protein peptides and aptamers, which facilitate targeted release and heightened bioavailability. Simultaneously, DNA carriers have emerged as a cutting-edge class of active-targeting structures, connecting active targeting agents and illustrating their potential in ocular drug delivery applications. This review aims to consolidate recent findings regarding the optimization of various nanoparticles, i.e., hydrogel-based systems, incorporating both passive and active targeting agents for ocular drug delivery, thereby identifying novel mechanisms and strategies. Furthermore, the review delves into the potential application of DNA nanostructures, exploring their role in the development of targeted drug delivery approaches within the field of ocular therapy.
凝胶或颗粒形式的纳米医学在增强眼部给药系统中的被动和主动靶向方面具有巨大潜力。眼睛的复杂屏障，以紧密相连的组织结构的复杂网络为例，给药物给药带来了重大挑战。利用工程纳米医学的能力提供了一种有前景的方法来增强药物渗透，特别是通过蛋白质肽和适配体等主动靶向剂，它们有助于靶向释放和提高生物利用度。同时，DNA载体已成为一类前沿的主动靶向结构，连接主动靶向剂并展示了它们在眼部给药应用中的潜力。本综述旨在整合关于各种纳米颗粒（即基于水凝胶的系统）优化的最新发现，这些系统结合了用于眼部给药的被动和主动靶向剂，从而确定新的机制和策略。此外，该综述深入探讨了DNA纳米结构的潜在应用，探索它们在眼部治疗领域靶向给药方法开发中的作用。
