Department of Microbiology, University of Washington, Seattle, Washington 98195, USA.
Cell Microbiol. 2011 Aug;13(8):1122-9. doi: 10.1111/j.1462-5822.2011.01619.x. Epub 2011 Jun 24.
Cyclic-di-GMP (c-di-GMP) regulates many important bacterial processes. Freely diffusible intracellular c-di-GMP is determined by the action of metabolizing enzymes that allow integration of numerous input signals. c-di-GMP specifically regulates multiple cellular processes by binding to diverse target molecules. This review highlights important questions in research into the mechanisms of c-di-GMP signalling and its role in bacterial physiology.
环二鸟苷酸（c-di-GMP）调节许多重要的细菌过程。可扩散的细胞内 c-di-GMP 由代谢酶的作用决定，这些酶允许整合众多输入信号。c-di-GMP 通过与多种靶分子结合特异性地调节多种细胞过程。这篇综述强调了 c-di-GMP 信号转导机制及其在细菌生理学中的作用研究中的重要问题。
