Institute of Neuroscience and Medicine, INM-2, Research Centre Jülich, Jülich, Germany.
Neuroimage. 2011 Oct 1;58(3):860-9. doi: 10.1016/j.neuroimage.2011.05.089. Epub 2011 Jun 25.
Attentional orienting can be modulated by stimulus-driven bottom-up as well as task-dependent top-down processes. In a recent study we investigated the interaction of both processes in a manual stimulus-response compatibility task. Whereas the intraparietal sulcus (IPS) and the dorsal premotor cortex (dPMC) were involved in orienting towards the stimulus side facilitating congruent motor responses, the right temporoparietal junction (TPJ), right dorsolateral prefrontal cortex (DLPFC) as well as the preSMA sustained top-down control processes involved in voluntary reorienting. Here we used dynamic causal modelling to investigate the contributions and task-dependent interactions between these regions. Thirty-six models were tested, all of which included bilateral IPS, dPMC and primary motor cortex (M1) as a network transforming visual input into motor output as well as the right TPJ, right DLPFC and the preSMA as task-dependent top-down regions influencing the coupling within the dorsal network. Our data showed the right temporoparietal junction to play a mediating role during attentional reorienting processes by modulating the inter-hemispheric balance between both IPS. Analysis of connection strength supported the proposed role of the preSMA in controlling motor responses promoting or suppressing activity in primary motor cortex. As the results did not show a clear tendency towards a role of the right DLPFC, we propose this region, against the usual interpretation of an inhibitory influence in stimulus-response compatibility tasks, to subserve generic monitoring processes. Our DCM study hence provides evidence for context-dependent top-down control of right TPJ and DLPFC as well as the preSMA in stimulus-response compatibility.
注意定向可以通过刺激驱动的自下而上以及任务依赖的自上而下的过程来调节。在最近的一项研究中，我们在手动刺激-反应相容性任务中研究了这两个过程的相互作用。虽然顶内沟（IPS）和背侧运动前皮层（dPMC）参与朝向刺激侧的定向，促进了一致的运动反应，但右侧颞顶交界处（TPJ）、右侧背外侧前额叶皮层（DLPFC）以及前扣带回参与了自愿重新定向的自上而下的持续控制过程。在这里，我们使用动态因果建模来研究这些区域之间的贡献和任务依赖性相互作用。测试了 36 个模型，所有模型都包括双侧 IPS、dPMC 和初级运动皮层（M1）作为将视觉输入转化为运动输出的网络，以及右侧 TPJ、右侧 DLPFC 和 preSMA 作为影响背侧网络内耦合的任务依赖的自上而下区域。我们的数据表明，右侧颞顶交界处通过调节 IPS 之间的半球间平衡，在注意力重新定向过程中发挥了中介作用。连接强度的分析支持了 preSMA 在控制运动反应中的作用，促进或抑制了初级运动皮层的活动。由于结果没有显示出右侧 DLPFC 明显的作用倾向，我们提出该区域在刺激-反应相容性任务中起通用监测过程的作用，而不是通常解释的抑制影响。因此，我们的 DCM 研究为刺激-反应相容性中右侧 TPJ、DLPFC 和 preSMA 的上下文依赖的自上而下控制提供了证据。
