Thysell H, Hagstam K E, Lindergård B, Lindholm T
Scand J Urol Nephrol. 1979;13(1):95-9. doi: 10.3109/00365597909180006.
The adrenocortical function of 59 patients on regular hemodialysis treatment was tested on 105 occasions by measuring the 30-min response of free plasma 11-hydroxycorticosteroids (11-OHCS) after intramuscular injection of 0.25 mg Synacthen (beta1-24-corticotrophin). The morning basal levels of 11-OHCS were within the normal range. The increase of 11-OHCS after injection of Synacthen was less than normal in 25% of the patients. In 9 patients with a low response an extended Synacthen test was performed. This caused a normal increase in plasma 11-OHCS but the response came later than in normal persons. After 0.25 mg Synacthen intramuscularly the 30-min response of 11-OHCS seemed to be lower on the first day than on the second day after dialysis. The present study supports the view that the pituitary-adrenocortical system is essentially intact in patients on regular hemodialysis treatment.
通过肌注0.25mg辛纳科（β1 - 24促肾上腺皮质激素）后测定游离血浆11 - 羟基皮质类固醇（11 - OHCS）30分钟的反应，对59例接受定期血液透析治疗的患者进行了105次肾上腺皮质功能检测。11 - OHCS的晨间基础水平在正常范围内。25%的患者注射辛纳科后11 - OHCS的升高低于正常水平。对9例反应低下的患者进行了延长的辛纳科试验。这使得血浆11 - OHCS出现正常升高，但反应比正常人延迟。肌注0.25mg辛纳科后，11 - OHCS的30分钟反应在透析后的第一天似乎低于第二天。本研究支持这样的观点，即垂体 - 肾上腺皮质系统在接受定期血液透析治疗的患者中基本完整。
