文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

三叉神经感觉主核尾侧亚核在持续性面口痛中的作用。

The role of trigeminal interpolaris-caudalis transition zone in persistent orofacial pain.

机构信息

Department of Neural and Pain Sciences, Dental School; & Program in Neuroscience, University of Maryland, Baltimore, MD 21201-1586, USA.

出版信息

Int Rev Neurobiol. 2011;97:207-25. doi: 10.1016/B978-0-12-385198-7.00008-4.

DOI:10.1016/B978-0-12-385198-7.00008-4
PMID:21708312
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3257052/
Abstract

Previous studies have established the role of the medullary dorsal horn or the subnucleus caudalis of the spinal trigeminal complex, a homolog of the dorsal horn of the spinal cord, in trigeminal pain processing. In addition to the medullary dorsal horn, recent studies have pointed out increased excitability and sensitization of trigeminal interpolaris and caudalis transition zone (Vi/Vc) following deep orofacial injury, involving neuron-glia-cytokine interactions. The Vi/Vc transition zone accesses rostral brain regions that are important for descending pain modulation, and somatovisceral and somatoautonomic processing and plays a unique role in coordinating trigeminal nocifensive responses.

摘要

先前的研究已经确立了延髓背角或三叉神经脊束核尾侧亚核（脊髓背角的同源物）在三叉神经痛处理中的作用。除了延髓背角，最近的研究还指出，深部口腔面部损伤后，三叉神经节中脑桥核和尾核过渡区（Vi/Vc）的兴奋性和敏感性增加，涉及神经元-神经胶质-细胞因子相互作用。Vi/Vc 过渡区与控制下行性疼痛调制、躯体-内脏和躯体-自主加工的脑区相连，在协调三叉神经伤害性反应方面发挥着独特的作用。

相似文献

[1]
The role of trigeminal interpolaris-caudalis transition zone in persistent orofacial pain.

Int Rev Neurobiol. 2011

[2]
Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia: the effects of interleukin-10 and glial inhibitors.

Mol Pain. 2009-12-21

[3]
Brainstem mechanisms of persistent pain following injury.

J Orofac Pain. 2004

[4]
Selective distribution and function of primary afferent nociceptive inputs from deep muscle tissue to the brainstem trigeminal transition zone.

J Comp Neurol. 2006-9-20

[5]
Trigeminal-rostral ventromedial medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injury.

Mol Pain. 2012-10-23

[6]
Trigeminal transition zone/rostral ventromedial medulla connections and facilitation of orofacial hyperalgesia after masseter inflammation in rats.

J Comp Neurol. 2005-12-26

[7]
Response properties of nociceptive and non-nociceptive neurons in the rat's trigeminal subnucleus caudalis (medullary dorsal horn) related to cutaneous and deep craniofacial afferent stimulation and modulation by diffuse noxious inhibitory controls.

Pain. 1990-6

[8]
Central serotonin 3 receptors play an important role in the modulation of nociceptive neural activity of trigeminal subnucleus caudalis and nocifensive orofacial behavior in rats with persistent temporomandibular joint inflammation.

Neuroscience. 2005

[9]
Masseteric inflammation-induced Fos protein expression in the trigeminal interpolaris/caudalis transition zone: contribution of somatosensory-vagal-adrenal integration.

Brain Res. 1999-10-23

[10]
Differential rostral projections of caudal brainstem neurons receiving trigeminal input after masseter inflammation.

J Comp Neurol. 2003-10-13

引用本文的文献

[1]
Inhibitory action of citronellol on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in juvenile mice.

Korean J Physiol Pharmacol. 2025-9-1

[2]
Method for cryopreservation of brainstem pons and medulla oblongata tissue from Sprague Dawley rats for establishing primary mixed neuron-glia cell cultures.

Brain Res. 2025-8-1

[3]
Modulatory Processes in Craniofacial Pain States.

Adv Neurobiol. 2024

[4]
Divergent changes in PBN excitability in a mouse model of neuropathic pain.

eNeuro. 2024-2-8

[5]
Naringenin modulates GABA mediated response in a sexdependent manner in substantia gelatinosa neurons of trigeminal subnucleus caudalis in immature mice.

Korean J Physiol Pharmacol. 2024-1-1

[6]
Electroacupuncture exerts prolonged analgesic and neuroprotective effects in a persistent dental pain model induced by multiple dental pulp injuries: GABAergic interneurons-astrocytes interaction.

Front Immunol. 2023

[7]
GFAP-NpHR mediated optogenetic inhibition of trigeminal nucleus caudalis attenuates hypersensitive behaviors and thalamic discharge attributed to infraorbital nerve constriction injury.

J Headache Pain. 2023-10-11

[8]
Role of Neurotrophins in Orofacial Pain Modulation: A Review of the Latest Discoveries.

Int J Mol Sci. 2023-8-4

[9]
Direct and Indirect Nociceptive Input from the Trigeminal Dorsal Horn to Pain-Modulating Neurons in the Rostral Ventromedial Medulla.

J Neurosci. 2023-8-9

[10]
Locus coeruleus-noradrenergic modulation of trigeminal pain: Implications for trigeminal neuralgia and psychiatric comorbidities.

Neurobiol Pain. 2023-3-20

本文引用的文献

[1]
Interactions between the immune and nervous systems in pain.

Nat Med. 2010-10-14

[2]
Ultraviolet irradiation of the eye and Fos-positive neurons induced in trigeminal brainstem after intravitreal or ocular surface transient receptor potential vanilloid 1 activation.

Neuroscience. 2010-7-17

[3]
Behavioral and neurophysiological correlates of nociception in an animal model of photokeratitis.

Neuroscience. 2010-4-24

[4]
Microinjection of IL-1β into the trigeminal transition zone produces bilateral NMDA receptor-dependent orofacial hyperalgesia involving descending circuitry.

Open Pain J. 2009-1-1

[5]
Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia: the effects of interleukin-10 and glial inhibitors.

Mol Pain. 2009-12-21

[6]
N-Methyl-D-aspartate receptor (NMDAR) independent maintenance of inflammatory pain.

Pain. 2009-12-11

[7]
Increased phosphorylation of extracellular signal-regulated kinase in trigeminal nociceptive neurons following propofol administration in rats.

J Pain. 2009-6

[8]
Regulation of the trigeminal NR1 subunit expression induced by inflammation of the temporomandibular joint region in rats.

Pain. 2009-1

[9]
Supraspinal glial-neuronal interactions contribute to descending pain facilitation.

J Neurosci. 2008-10-15

[10]
Inhibition of NMDA-induced outward currents by interleukin-1beta in hippocampal neurons.

Biochem Biophys Res Commun. 2008-8-8

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索