免疫系统与神经系统在疼痛中的相互作用。
Interactions between the immune and nervous systems in pain.
机构信息
Department of Neural and Pain Sciences, Dental School & Program in Neuroscience, University of Maryland, Baltimore, Maryland, USA.
出版信息
Nat Med. 2010 Nov;16(11):1267-76. doi: 10.1038/nm.2234. Epub 2010 Oct 14.
Abstract
Immune cells and glia interact with neurons to alter pain sensitivity and to mediate the transition from acute to chronic pain. In response to injury, resident immune cells are activated and blood-borne immune cells are recruited to the site of injury. Immune cells not only contribute to immune protection but also initiate the sensitization of peripheral nociceptors. Through the synthesis and release of inflammatory mediators and interactions with neurotransmitters and their receptors, the immune cells, glia and neurons form an integrated network that coordinates immune responses and modulates the excitability of pain pathways. The immune system also reduces sensitization by producing immune-derived analgesic and anti-inflammatory or proresolution agents. A greater understanding of the role of the immune system in pain processing and modulation reveals potential targets for analgesic drug development and new therapeutic opportunities for managing chronic pain.
摘要
免疫细胞和神经胶质细胞与神经元相互作用，改变疼痛敏感性，并介导急性疼痛向慢性疼痛的转变。在受伤时，常驻免疫细胞被激活，血液来源的免疫细胞被招募到损伤部位。免疫细胞不仅有助于免疫保护，还启动了外周伤害感受器的敏化。通过合成和释放炎症介质，并与神经递质及其受体相互作用，免疫细胞、神经胶质细胞和神经元形成一个整合的网络，协调免疫反应并调节疼痛通路的兴奋性。免疫系统还通过产生免疫源性的镇痛、抗炎或促解决介质来减少敏化。更深入地了解免疫系统在疼痛处理和调节中的作用，揭示了开发镇痛药物的潜在靶点和管理慢性疼痛的新治疗机会。
相似文献
1
Interactions between the immune and nervous systems in pain.免疫系统与神经系统在疼痛中的相互作用。
Nat Med. 2010 Nov;16(11):1267-76. doi: 10.1038/nm.2234. Epub 2010 Oct 14.
2
[Research consortium Neuroimmunology and pain in the research network musculoskeletal diseases].[研究联盟：肌肉骨骼疾病研究网络中的神经免疫学与疼痛]
Z Rheumatol. 2018 May;77(Suppl 1):24-30. doi: 10.1007/s00393-018-0459-9.
3
The neuro-immune balance in neuropathic pain: involvement of inflammatory immune cells, immune-like glial cells and cytokines.神经病理性疼痛中的神经免疫平衡：炎症免疫细胞、免疫样胶质细胞和细胞因子的参与。
J Neuroimmunol. 2010 Dec 15;229(1-2):26-50. doi: 10.1016/j.jneuroim.2010.08.013. Epub 2010 Sep 25.
4
Perspectives in Pain Research 2014: Neuroinflammation and glial cell activation: The cause of transition from acute to chronic pain?2014年疼痛研究展望：神经炎症与胶质细胞激活——从急性疼痛转变为慢性疼痛的原因？
Scand J Pain. 2015 Jan 1;6(1):3-6. doi: 10.1016/j.sjpain.2014.10.002.
5
Nociceptor Sensory Neuron-Immune Interactions in Pain and Inflammation.疼痛与炎症中伤害感受器感觉神经元-免疫相互作用
Trends Immunol. 2017 Jan;38(1):5-19. doi: 10.1016/j.it.2016.10.001. Epub 2016 Oct 25.
6
Contribution of the activation of satellite glia in sensory ganglia to pathological pain.感觉神经节中卫星神经胶质细胞的激活对病理性疼痛的作用。
Neurosci Biobehav Rev. 2009 Jun;33(6):784-92. doi: 10.1016/j.neubiorev.2008.12.005. Epub 2009 Jan 9.
7
Peripheral Nociceptors as Immune Sensors in the Development of Pain and Itch.外周伤害感受器作为疼痛和瘙痒发生过程中的免疫传感器
Adv Exp Med Biol. 2016;904:77-85. doi: 10.1007/978-94-017-7537-3_6.
8
Role of interleukin-1beta during pain and inflammation.白细胞介素-1β在疼痛和炎症过程中的作用。
Brain Res Rev. 2009 Apr;60(1):57-64. doi: 10.1016/j.brainresrev.2008.12.020. Epub 2008 Dec 31.
9
The role of chemical transmitters in neuron-glia interaction and pain in sensory ganglion.化学递质在感觉神经节神经元-神经胶质相互作用和疼痛中的作用。
Neurosci Biobehav Rev. 2020 Jan;108:393-399. doi: 10.1016/j.neubiorev.2019.11.019. Epub 2019 Nov 27.
10
Immune Actions on the Peripheral Nervous System in Pain.免疫对疼痛外周神经系统的作用。
Int J Mol Sci. 2021 Feb 1;22(3):1448. doi: 10.3390/ijms22031448.
引用本文的文献
1
Obstructive Sleep Apnea and Postoperative Hyperalgesia in Bariatric Surgery: A Prospective Observational Cohort Study.肥胖症手术中的阻塞性睡眠呼吸暂停与术后痛觉过敏：一项前瞻性观察队列研究
J Pain Res. 2025 Sep 2;18:4527-4538. doi: 10.2147/JPR.S508324. eCollection 2025.
2
Phytochemical Modulators of Nociception: A Review of Cannabis Terpenes in Chronic Pain Syndromes.伤害感受的植物化学调节剂：慢性疼痛综合征中大麻萜类化合物的综述
Pharmaceuticals (Basel). 2025 Jul 24;18(8):1100. doi: 10.3390/ph18081100.
3
The Bed Nucleus of the Stria Terminalis-Paraventricular Nucleus of the Hypothalamus Neural Circuit Regulates Neuropathic Pain Through the Brain-Spleen Axis.终纹床核-下丘脑室旁核神经回路通过脑-脾轴调节神经性疼痛。
Neurosci Bull. 2025 Aug 20. doi: 10.1007/s12264-025-01454-9.
4
Topical oleic acid reduces nociception and inflammation in a UVB radiation-induced sunburn model in mice.局部应用油酸可减轻小鼠紫外线B辐射诱导的晒伤模型中的伤害感受和炎症反应。
Naunyn Schmiedebergs Arch Pharmacol. 2025 Aug 13. doi: 10.1007/s00210-025-04509-w.
5
Scorpion Venom-Induced Nociceptive Responses Depend on TRPV1, Immune Cells, and Pro-Inflammatory Cytokines.蝎毒诱导的伤害性反应取决于瞬时受体电位香草酸亚型1（TRPV1）、免疫细胞和促炎细胞因子。
Toxins (Basel). 2025 Jun 30;17(7):332. doi: 10.3390/toxins17070332.
6
The Power of Movement: How Exercise Influences Chemotherapy-Induced Peripheral Neuropathy.运动的力量：运动如何影响化疗引起的周围神经病变
Biomedicines. 2025 May 1;13(5):1103. doi: 10.3390/biomedicines13051103.
7
Evaluation of the Therapeutic Efficacy of Entrapment Neuropathy Unties (ENU) Pharmacopuncture in Neuropathic Pain Caused by Sciatic Nerve Ligation in Mice.评估卡压性神经病松解（ENU）穴位注射疗法对小鼠坐骨神经结扎所致神经性疼痛的治疗效果。
J Pain Res. 2025 May 12;18:2393-2405. doi: 10.2147/JPR.S519298. eCollection 2025.
8
Paeonol Relieves Chronic Neuropathic Pain by Reducing Communication Between Schwann Cells and Macrophages in the Dorsal Root Ganglia After Injury.丹皮酚通过减少损伤后背根神经节中雪旺细胞与巨噬细胞之间的通讯来缓解慢性神经性疼痛。
Int J Mol Sci. 2025 Apr 22;26(9):3964. doi: 10.3390/ijms26093964.
9
Multisite Chronic Pain and the Risk of Breast Cancer and Its Subtypes: A Mendelian Randomization Study.多部位慢性疼痛与乳腺癌及其亚型风险：一项孟德尔随机化研究
J Pain Res. 2025 May 7;18:2343-2357. doi: 10.2147/JPR.S489703. eCollection 2025.
10
Genetics- and age-driven neuroimmune and disc changes underscore herniation susceptibility and pain-associated behaviors in SM/J mice.基因和年龄驱动的神经免疫及椎间盘变化突出了SM/J小鼠的椎间盘突出易感性和疼痛相关行为。
Sci Adv. 2025 Apr 25;11(17):eado6847. doi: 10.1126/sciadv.ado6847. Epub 2025 Apr 23.
本文引用的文献
1
Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling.小胶质细胞/巨噬细胞 GRK2 决定外周 IL-1β诱导的痛觉过敏持续时间：脊髓 CX3CR1、p38 和 IL-1 信号的贡献。
Pain. 2010 Sep;150(3):550-560. doi: 10.1016/j.pain.2010.06.015. Epub 2010 Jul 6.
2
Antihyperalgesic and antiallodynic effect of sirolimus in neuropathic pain and the role of cytokines in this effect.西罗莫司在神经病理性疼痛中的抗痛觉过敏和抗异常感觉作用及细胞因子在此作用中的作用。
Neurosci Lett. 2010 Aug 30;481(1):17-20. doi: 10.1016/j.neulet.2010.06.039. Epub 2010 Jun 18.
3
Mechanisms of peripheral immune-cell-mediated analgesia in inflammation: clinical and therapeutic implications.外周免疫细胞介导的炎症镇痛机制：临床和治疗意义。
Trends Pharmacol Sci. 2010 Sep;31(9):427-33. doi: 10.1016/j.tips.2010.05.008. Epub 2010 Jun 28.
4
SOCS3-mediated blockade of JAK/STAT3 signaling pathway reveals its major contribution to spinal cord neuroinflammation and mechanical allodynia after peripheral nerve injury.SOCS3 介导的 JAK/STAT3 信号通路阻断揭示其在外周神经损伤后对脊髓神经炎症和机械性痛觉过敏的主要贡献。
J Neurosci. 2010 Apr 21;30(16):5754-66. doi: 10.1523/JNEUROSCI.5007-09.2010.
5
Endomorphins in rheumatoid arthritis, osteoarthritis, and experimental arthritis.内吗啡肽在类风湿关节炎、骨关节炎和实验性关节炎中的作用。
Ann N Y Acad Sci. 2010 Apr;1193:117-22. doi: 10.1111/j.1749-6632.2009.05294.x.
6
Neuregulin-ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injury.神经调节蛋白-ErbB 信号促进小胶质细胞增殖和趋化，导致外周神经损伤后的小胶质细胞增生和疼痛。
J Neurosci. 2010 Apr 14;30(15):5437-50. doi: 10.1523/JNEUROSCI.5169-09.2010.
7
Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions.解析物 RvE1 和 RvD1 通过中枢和外周作用减轻炎性疼痛。
Nat Med. 2010 May;16(5):592-7, 1p following 597. doi: 10.1038/nm.2123. Epub 2010 Apr 11.
8
Pattern recognition receptors and inflammation.模式识别受体与炎症。
Cell. 2010 Mar 19;140(6):805-20. doi: 10.1016/j.cell.2010.01.022.
9
Do astrocytes really exocytose neurotransmitters?星形胶质细胞真的会胞吐神经递质吗？
Nat Rev Neurosci. 2010 Apr;11(4):227-38. doi: 10.1038/nrn2803.
10
Release of plasmid DNA-encoding IL-10 from PLGA microparticles facilitates long-term reversal of neuropathic pain following a single intrathecal administration.PLGA 微球中质粒 DNA 编码的 IL-10 的释放促进单次鞘内给药后神经病理性疼痛的长期逆转。
Pharm Res. 2010 May;27(5):841-54. doi: 10.1007/s11095-010-0077-y. Epub 2010 Mar 12.
Zotero 插件