The University of Texas Medical Branch, Houston, Texas 77002, USA.
J Surg Educ. 2011 Jul-Aug;68(4):320-5. doi: 10.1016/j.jsurg.2011.02.001. Epub 2011 Mar 25.
Fibromatosis or desmoid tumor is a benign, slow-growing fibroblastic neoplasm originating from musculoaponeurotic stromal elements. These tumors are characterized by an infiltrative and locally aggressive growth pattern, frequent recurrences, but no metastatic potential. The etiology is unknown, but these tumors have been associated with trauma and genetic disorders. Breast fibromatosis is exceedingly rare and often misdiagnosed, comprising only 0.2% of breast tumors. Clinically, it might mimic other breast lesions, such as carcinoma. Only approximately 6 case series and 100 case reports of this disorder affecting the breast are documented, and only 5 cases of bilateral breast fibromatosis have been reported. We describe the case of a 20-year-old woman who presented to our institution with firm, nontender masses palpable in both breasts. Prior ultrasound was suspicious for carcinoma, and breast core biopsies were suggestive of phyllodes tumor. An excisional biopsy was necessary to establish the diagnosis of breast fibromatosis for both masses. A review of articles published on desmoid tumors and breast fibromatosis was performed with emphasis on articles published in the last 10 years. Fibromatosis should be considered in the differential diagnosis of patients presenting with hard breast lumps suspicious of other diseases.
纤维瘤病或韧带样瘤是一种良性、生长缓慢的成纤维细胞肿瘤，起源于肌纤维膜的间质细胞。这些肿瘤的特点是具有浸润性和局部侵袭性生长模式，常复发，但无转移潜能。病因不明，但这些肿瘤与创伤和遗传疾病有关。乳腺纤维瘤病极为罕见，常被误诊，仅占乳腺肿瘤的 0.2%。临床上，它可能类似于其他乳腺病变，如癌。目前仅有约 6 个关于这种影响乳腺的疾病的病例系列和 100 个病例报告，仅有 5 例双侧乳腺纤维瘤病的报告。我们描述了一例 20 岁女性的病例，她因触及双侧乳房内的坚实、无触痛肿块而就诊于我院。之前的超声检查怀疑为癌，乳腺核心活检提示为叶状肿瘤。为了明确双侧肿块的诊断，需要进行切除活检。我们对发表的关于韧带样瘤和乳腺纤维瘤病的文章进行了回顾，重点是过去 10 年发表的文章。对于表现为硬乳腺肿块且怀疑为其他疾病的患者，应考虑纤维瘤病作为鉴别诊断。
