Sogunro Olutayo, Joseph-Pauline Sahlia, Oluyemi Eniola, Lee Seoho, Pinco Jeffrey
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Graduate Medical Education, Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA.
AME Case Rep. 2024 Dec 16;9:24. doi: 10.21037/acr-24-84. eCollection 2025.
Fibromatosis of the breast, also known as desmoid-type fibromatosis (DTF), is a rare tumor marked by the development of non-metastatic, locally aggressive tumors in breast tissue. It represents only 0.2% of all breast tumors. It is a nonmalignant tumor that often resembles cancer in both its clinical presentation and radiologic imaging characteristics, posing unique diagnostic and management challenges.
This is a case report of a 34-year-old female with a history of bilateral silicone implant placement who presented with bilateral breast masses. She reported a 6-month history of a 1-cm firm, palpable mass in the right breast without associated pain or growth. She had a family history of breast, pancreatic, and prostate cancer but no significant past medical history. Ultrasound-guided biopsy of the right breast and magnetic resonance imaging (MRI)-guided biopsy of the left breast both revealed fibromatoses. She underwent bilateral excisional biopsies and surgical pathology confirmed breast fibromatosis in the background of benign breast tissue with fibrocystic changes. The patient had an uncomplicated post-operative course.
This case report of a patient with prior breast augmentation surgery highlights the clinical presentation, diagnosis, and management of breast fibromatosis. The intricate relationship between desmoid tumors and factors such as tissue injury, surgical trauma, exogenous hormone exposure, and genetics is discussed. Ultimately, comprehensive diagnostic and therapeutic approaches with individualized treatment strategies are essential for managing fibromatosis effectively.
乳腺纤维瘤病，也称为韧带样型纤维瘤病（DTF），是一种罕见的肿瘤，其特征是在乳腺组织中发展出非转移性、局部侵袭性肿瘤。它仅占所有乳腺肿瘤的0.2%。这是一种非恶性肿瘤，其临床表现和放射影像学特征通常与癌症相似，带来了独特的诊断和管理挑战。
这是一例34岁女性的病例报告，该女性有双侧硅胶植入史，出现双侧乳腺肿块。她报告右侧乳房有一个1厘米大小、质地坚硬、可触及的肿块，已有6个月，无相关疼痛或生长。她有乳腺癌、胰腺癌和前列腺癌家族史，但既往无重大病史。右侧乳房超声引导下活检和左侧乳房磁共振成像（MRI）引导下活检均显示为纤维瘤病。她接受了双侧切除活检，手术病理证实为良性乳腺组织伴纤维囊性变背景下的乳腺纤维瘤病。患者术后恢复顺利。
该例有隆胸手术史患者的病例报告突出了乳腺纤维瘤病的临床表现、诊断和管理。讨论了韧带样肿瘤与组织损伤、手术创伤、外源性激素暴露和遗传等因素之间的复杂关系。最终，采用综合诊断和治疗方法并制定个体化治疗策略对于有效管理纤维瘤病至关重要。
