Oishi T, Kubota K
Department of Neurophysiology, Kyoto University, Aichi, Japan.
Neurosci Res. 1990 Jul;8(3):202-9. doi: 10.1016/0168-0102(90)90021-6.
Local injection of a GABA (gamma-aminobutyric acid) antagonist, bicuculline, into Brodmann's area 8 (Walker's areas 8A and 45) of the monkey prefrontal cortex induced movements of the contralateral forelimb in 4 monkeys that were well-trained to perform a two-choice visual discrimination GO/NO-GO task by appropriate release of the hand from a lever. But the same procedures of injection in two naive monkeys did not. These results indicate that, during learning of the task, a new structure responsible for learned movement of the forelimb was made in area 8 and was disinhibited by bicuculline and, furthermore, they suggest that inhibitory GABA neurons suppress tonically efferent neurons associated with the initiation of movement.
向4只经过良好训练、能通过从杠杆上适当松开手来执行二选一视觉辨别“执行/不执行”任务的猴子的前额叶皮质布罗德曼8区（沃克8A区和45区）局部注射γ-氨基丁酸（GABA）拮抗剂荷包牡丹碱，诱发了对侧前肢运动。但对两只未经训练的猴子进行相同的注射程序却未出现这种情况。这些结果表明，在任务学习过程中，8区形成了一个负责前肢习得性运动的新结构，且该结构被荷包牡丹碱去抑制，此外，这些结果还表明，抑制性GABA神经元对与运动起始相关的传出神经元具有紧张性抑制作用。
