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本文引用的文献

1
Comparative in vitro activities of the novel antibacterial finafloxacin against selected Gram-positive and Gram-negative bacteria tested in Mueller-Hinton broth and synthetic urine.新型抗菌药 finafloxacin 对 Mueller-Hinton 肉汤和合成尿中测试的部分革兰氏阳性和革兰氏阴性细菌的体外比较活性。
Antimicrob Agents Chemother. 2011 Apr;55(4):1814-8. doi: 10.1128/AAC.00886-10. Epub 2011 Jan 18.
2
Antibacterial activity of finafloxacin under different pH conditions against isogenic strains of Escherichia coli expressing combinations of defined mechanisms of fluoroquinolone resistance.不同 pH 条件下非那沙星对表达不同氟喹诺酮耐药机制组合的同源大肠埃希菌的抗菌活性。
J Antimicrob Chemother. 2010 Dec;65(12):2530-3. doi: 10.1093/jac/dkq375. Epub 2010 Oct 12.
3
Activity of the investigational fluoroquinolone finafloxacin against ciprofloxacin-sensitive and -resistant Acinetobacter baumannii isolates.研究氟喹诺酮类药物非那沙星对环丙沙星敏感和耐药鲍曼不动杆菌分离株的活性。
Antimicrob Agents Chemother. 2010 Apr;54(4):1613-5. doi: 10.1128/AAC.01637-09. Epub 2010 Jan 25.
4
Hyperinflammation in airways of cystic fibrosis patients: what's new?囊性纤维化患者气道中的过度炎症：有何新进展？
Expert Rev Mol Diagn. 2008 Jul;8(4):359-63. doi: 10.1586/14737159.8.4.359.
5
Effect of pH on the in vitro activity of and propensity for emergence of resistance to fluoroquinolones, macrolides, and a ketolide.pH对氟喹诺酮类、大环内酯类和酮内酯类药物体外活性及耐药性产生倾向的影响。
Infection. 2005 Dec;33 Suppl 2:36-43. doi: 10.1007/s15010-005-8206-y.
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Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions.在囊性纤维化气道条件下，酸化亚硝酸盐衍生物对黏液型铜绿假单胞菌的厌氧杀伤作用。
J Clin Invest. 2006 Feb;116(2):436-46. doi: 10.1172/JCI24684. Epub 2006 Jan 26.
7
Antimicrobial safety: focus on fluoroquinolones.抗菌药物安全性：聚焦氟喹诺酮类药物
Clin Infect Dis. 2005 Jul 15;41 Suppl 2:S144-57. doi: 10.1086/428055.
8
Conditions affecting the results of susceptibility testing for the quinolone compounds.
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在标准和酸性条件下，新型 pH 激活氟喹诺酮类药物法氟沙星的体外活性谱。

In vitro spectrum of activity of finafloxacin, a novel, pH-activated fluoroquinolone, under standard and acidic conditions.

机构信息

MerLion Pharmaceuticals GmbH, Robert-Rössle Strasse 10, Berlin, Germany.

出版信息

Antimicrob Agents Chemother. 2011 Sep;55(9):4394-7. doi: 10.1128/AAC.00833-10. Epub 2011 Jun 27.

DOI:10.1128/AAC.00833-10
PMID:21709094
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3165343/
Abstract

Finafloxacin is a novel fluoroquinolone that exhibits enhanced antibacterial activity under acidic conditions. The aim of this study was to define the in vitro pH-activity relationship. Finafloxacin exhibited optimal antibacterial activity between pH 5.0 and 6.0 at which MICs were 4- to 8-fold lower than those determined at neutral pH. These observations were then confirmed against a larger collection of bacteria. These data suggest that finafloxacin could potentially offer a therapeutic advantage within acidic foci of infection.

摘要

菲那沙星是一种新型氟喹诺酮类药物，在酸性条件下表现出增强的抗菌活性。本研究旨在确定体外 pH-活性关系。菲那沙星在 pH5.0 到 6.0 之间表现出最佳的抗菌活性，此时 MIC 比在中性 pH 时低 4 到 8 倍。这些观察结果随后在更大的细菌集合中得到了证实。这些数据表明，菲那沙星在感染的酸性病灶内可能具有潜在的治疗优势。