非奈利酮对呼吸道病原体组的活性。
Activity of Finafloxacin against Panels of Respiratory Pathogens.
作者信息
Harding Sarah V, Barnes Kay B, Hawser Stephen, Bentley Christine E, Vente Andreas
机构信息
Defence Science and Technology Laboratory, Salisbury SP4 0JQ, UK.
Department of Respiratory Sciences, University of Leicester, Leicester LE1 7RH, UK.
出版信息
Antibiotics (Basel). 2023 Jun 23;12(7):1096. doi: 10.3390/antibiotics12071096.
Abstract
This study determined the activity of finafloxacin against panels of bacterial strains, representative of those associated with infection in cystic fibrosis patients and predominately isolated from clinical cases of respiratory disease. Many of these isolates were resistant to various antimicrobials evaluated including the aminoglycosides, cephalosporins, carbapenems and fluoroquinolones. Broth microdilution assays were performed at neutral and acidic pH, to determine antimicrobial activity. Finafloxacin demonstrated superior activity at reduced pH for all of the bacterial species investigated, highlighting the requirement to determine the activity of antimicrobials in host-relevant conditions.
摘要
本研究测定了非那沙星对一系列细菌菌株的活性，这些菌株代表了与囊性纤维化患者感染相关的菌株，且主要从呼吸道疾病临床病例中分离得到。这些分离株中有许多对包括氨基糖苷类、头孢菌素类、碳青霉烯类和氟喹诺酮类在内的多种评估抗菌药物耐药。在中性和酸性pH条件下进行肉汤微量稀释试验，以确定抗菌活性。对于所有研究的细菌种类，非那沙星在较低pH值时表现出更强的活性，这突出了在与宿主相关的条件下测定抗菌药物活性的必要性。
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