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本文引用的文献

1
Efficacy and immunogenicity of Mycobacterium bovis DeltaRD1 against aerosol M. bovis infection in neonatal calves.牛分枝杆菌DeltaRD1对新生犊牛气溶胶感染牛分枝杆菌的效力和免疫原性。
Vaccine. 2009 Feb 18;27(8):1201-9. doi: 10.1016/j.vaccine.2008.12.018. Epub 2009 Jan 9.
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Genetic Manipulation of Mycobacterium tuberculosis.结核分枝杆菌的基因操作
Curr Protoc Microbiol. 2007 Aug;Chapter 10:Unit 10A.2. doi: 10.1002/9780471729259.mc10a02s6.
3
Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis.巯基乙醇生物合成对于结核分枝杆菌对乙硫异烟胺的敏感性至关重要。
Mol Microbiol. 2008 Sep;69(5):1316-29. doi: 10.1111/j.1365-2958.2008.06365.x. Epub 2008 Jul 21.
4
Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.结核分枝杆菌inhA中一个点突变的转移解决了异烟肼的作用靶点问题。
Nat Med. 2006 Sep;12(9):1027-9. doi: 10.1038/nm1466. Epub 2006 Aug 13.
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Population genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobacterium tuberculosis.异烟肼耐药突变及耐多药结核分枝杆菌进化的群体遗传学研究
Antimicrob Agents Chemother. 2006 Aug;50(8):2640-9. doi: 10.1128/AAC.00112-06.
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Multicenter study of MTT and resazurin assays for testing susceptibility to first-line anti-tuberculosis drugs.用于检测对一线抗结核药物敏感性的MTT和刃天青试验的多中心研究
Int J Tuberc Lung Dis. 2005 Aug;9(8):901-6.
7
Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria.烟酰胺腺嘌呤二核苷酸（NADH）/烟酰胺腺嘌呤二核苷酸（NAD+）比值的改变介导了分枝杆菌对异烟肼和乙硫异烟胺的交叉耐药性。
Antimicrob Agents Chemother. 2005 Feb;49(2):708-20. doi: 10.1128/AAC.49.2.708-720.2005.
8
Sterilization of tubercle bacilli by isonicotinic acid hydrazide and the incidence of variants resistant to the drug in vitro.异烟肼对结核杆菌的杀菌作用及体外对该药耐药变异株的发生率
Am Rev Tuberc. 1952 Jun;65(6):765-7.
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In vitro studies on isonicotinic acid hydrazide.异烟肼的体外研究。
Am Rev Tuberc. 1952 Jun;65(6):761-4.
10
Resazurin microtiter assay plate testing of Mycobacterium tuberculosis susceptibilities to second-line drugs: rapid, simple, and inexpensive method.结核分枝杆菌对二线药物敏感性的刃天青微量滴定板检测：快速、简便且廉价的方法。
Antimicrob Agents Chemother. 2003 Nov;47(11):3616-9. doi: 10.1128/AAC.47.11.3616-3619.2003.

牛分枝杆菌中异烟肼和乙硫异烟胺的共同耐药性与巯基乙胺生物合成基因有关。

Coresistance to isoniazid and ethionamide maps to mycothiol biosynthetic genes in Mycobacterium bovis.

机构信息

Albert Einstein College of Medicine, Department of Microbiology and Immunology, 1300 Morris Park Ave., Bronx, NY 10461, USA.

出版信息

Antimicrob Agents Chemother. 2011 Sep;55(9):4422-3. doi: 10.1128/AAC.00564-11. Epub 2011 Jun 27.

DOI:10.1128/AAC.00564-11
PMID:21709101
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3165297/
Abstract

A search to identify new mechanisms of isoniazid resistance in Mycobacterium bovis led to the isolation of mutants defective in mycothiol biosynthesis due to mutations in genes coding for the glycosyltransferase (mshA) or the cysteine ligase (mshC). These mutants showed low-level resistance to isoniazid but were highly resistant to ethionamide. This study further illustrates that mutations in mycothiol biosynthesis genes may contribute to isoniazid or ethionamide resistance across mycobacterial species.

摘要

一项旨在确定结核分枝杆菌异烟肼耐药新机制的研究导致了由于编码糖基转移酶（mshA）或半胱氨酸连接酶（mshC）的基因突变而导致分枝菌酸生物合成缺陷的突变体的分离。这些突变体对异烟肼表现出低水平的耐药性，但对乙硫异烟胺高度耐药。本研究进一步表明，分枝菌酸生物合成基因的突变可能导致结核分枝杆菌和非结核分枝杆菌对异烟肼或乙硫异烟胺的耐药。