Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria.
Cells Tissues Organs. 2012;195(4):353-64. doi: 10.1159/000327012. Epub 2011 Jun 28.
The objective of this work was to characterize tibial plateau coverage and morphometric differences of the medial (MM) and lateral meniscus (LM) in a male reference cohort using three-dimensional imaging. Coronal multiplanar reconstructions of a sagittal double-echo steady state with water excitation magnetic resonance sequence (slice thickness: 1.5 mm, and in-plane resolution: 0.37 × 0.70 mm) were analyzed in 47 male participants without symptoms, signs or risk factors of knee osteoarthritis of the reference cohort of the Osteoarthritis Initiative. The medial and lateral tibial (LT) plateau cartilage area and the tibial, femoral and external surfaces of the MM and LM were manually segmented throughout the entire knee. This process was assisted by parallel inspection of a coronal intermediately weighted turbo spin echo sequence. Measures of tibial coverage, meniscus size, and meniscus position were computed three-dimensionally for the total menisci, the body, and the anterior and the posterior horn. The LM was found to cover a significantly greater (p < 0.001) proportion of the LT plateau (59 ± 6.8%) than the MM of the medial plateau (50 ± 5.5%). Whereas the volume of both menisci was similar (2.444 vs. 2.438 ml; p = 0.92), the LM displayed larger tibial and femoral surface areas (p < 0.05) and a smaller maximal (7.2 ± 1.0 vs. 7.7 ± 1.1 mm; p < 0.01) and mean thickness (2.7 ± 0.3 vs. 2.8 ± 0.3 mm; p < 0.001) than the medial one. Also, the LM displayed less (physiological) extrusion than the medial one. These data may guide strategies for meniscal tissue engineering and transplantation aiming to restore normal joint conditions.
本研究旨在利用三维成像技术对男性参考队列的内侧（MM）和外侧半月板（LM）进行胫骨平台覆盖和形态测量差异的特征描述。在没有膝关节骨关节炎症状、体征或危险因素的 47 名参考队列参与者中，使用矢状双回波稳态水激发磁共振序列进行冠状多平面重建（层厚：1.5mm，平面分辨率：0.37×0.70mm）。分析了内侧和外侧胫骨（LT）平台软骨面积以及 MM 和 LM 的胫骨、股骨和外侧面。手动分段整个膝关节的 MM 和 LM 的内、外侧胫骨覆盖、半月板大小和半月板位置的测量值进行了三维计算，包括半月板的体部和前、后角。研究结果表明，LM 覆盖 LT 平台的比例明显大于 MM（59±6.8% vs. 50±5.5%）（p<0.001）。尽管两个半月板的体积相似（2.444 与 2.438ml；p=0.92），但 LM 的胫骨和股骨表面积更大（p<0.05），最大厚度（7.2±1.0 与 7.7±1.1mm；p<0.01）和平均厚度（2.7±0.3 与 2.8±0.3mm；p<0.001）更小。此外，LM 的生理性外突程度小于 MM。这些数据可能为旨在恢复正常关节条件的半月板组织工程和移植策略提供指导。
