Harada Susumu, Moriyama Tatsuya, Tanaka Akira
Harada Skin Clinic.
Arerugi. 2011 Jun;60(6):708-13.
Two young women were suffered from several symptoms after the intake of royal jelly at their first time. According to the positive skin prick test reactions of raw royal jelly, royal jelly allergy was diagnosed. As the reasons why the symptoms appeared at the time of their first intake, we guessed the possibility that 1) they had been sensitized for royal jelly formerly, or 2) their symptoms were induced by the cross-reactivity between royal jelly and other allergens such as bee, honey and pollens. As to our cases, no related allergens were found in one case, but in another case co-existence of mugwort allergy was suspected from the results of both skin prick test and specific IgE titers. Originally royal jelly allergy has been regarded as class 1 allergic reaction developed by the sensitization of itself. But we speculated the possibility that there can also be cases of class 2 royal jelly allergy by the mechanism of cross-reaction with pollens.
两名年轻女性首次食用蜂王浆后出现了多种症状。根据生蜂王浆皮肤点刺试验阳性反应，诊断为蜂王浆过敏。对于首次食用时出现症状的原因，我们推测了两种可能性：1）她们之前已对蜂王浆致敏；2）其症状是由蜂王浆与其他过敏原（如蜜蜂、蜂蜜和花粉）之间的交叉反应引起的。就我们的病例而言，其中一例未发现相关过敏原，但另一例根据皮肤点刺试验和特异性IgE滴度结果怀疑同时存在艾蒿过敏。最初，蜂王浆过敏被认为是由自身致敏引起的1类过敏反应。但我们推测，也可能存在通过与花粉交叉反应机制引起的2类蜂王浆过敏病例。
