Lombardi C, Senna G E, Gatti B, Feligioni M, Riva G, Bonadonna P, Dama A R, Canonica G W, Passalacqua G
Dept. of Internal Medicine Sant'Orsola Hospital, Brescia, Italy.
Allergol Immunopathol (Madr). 1998 Nov-Dec;26(6):288-90.
Honey and royal jelly are complex etherogeneous mixtures of flowers' nectar, sugars, proteins and bee's glandular secretions. The existence of a type I hypersensitivity to honey is still matter of debate, while an aetiological role of Compositae pollens in the clinical manifestations following honey ingestion has been envisaged. We describe two cases of severe systemic reactions (anaphylaxis and generalized urticaria/angioedema) due to honey and royal jelly ingestion in patients sensitized to compositae (mugwort). Both patients had a skin and RAST positivity to mugwort and a positive prick-by-prick to the offending foods. Moreover, in one of the two patients the RAST-inhibition assay showed the strong cross-reactivity between the proteins of honey and mugwort and the SDS-PAGE analysis showed that the major proteic bands from honey and mugwort extracts are largely superimposable. Both the clinical data and the laboratory analysis support the hypothesis of a strict link between sensitization to compositae and adverse reactions to honey and jelly.
蜂蜜和蜂王浆是花蜜、糖类、蛋白质及蜜蜂腺体分泌物的复杂异质混合物。对蜂蜜存在I型超敏反应这一观点仍存在争议，而有人设想菊科花粉在摄入蜂蜜后的临床表现中具有病因学作用。我们描述了两例因摄入蜂蜜和蜂王浆而出现严重全身反应（过敏反应和全身性荨麻疹/血管性水肿）的病例，这两名患者对菊科植物（艾蒿）敏感。两名患者对艾蒿均有皮肤反应和RAST阳性，对致病食物进行点刺试验也呈阳性。此外，在两名患者中的一名，RAST抑制试验显示蜂蜜和艾蒿的蛋白质之间存在强烈交叉反应，SDS-PAGE分析表明蜂蜜和艾蒿提取物的主要蛋白条带基本重叠。临床数据和实验室分析均支持对菊科植物敏感与对蜂蜜和蜂王浆不良反应之间存在紧密联系这一假说。
