Moinade S, Gaillard G, Champeyroux J, Doly M, Glanddier Y, Dupuy-Cordez A
Sem Hop. 1978;54(37-40):1151-4.
The long-term effects of sulfonamides were studied by means of hyperinsulinemia tests in 82 diabetics over a period of 12 months (24 months for 30 of them). Whereas for those obese diabetics whose only treatment was dieting--alone or combined with biguanides--hyperinsulinemia attenuates itself as do also variations in glycemia, although some asynchronism remains, in those diabetics treated with sulfonamides--alone or in combination with other treatments--the insulinemia curve is hardly modified.
通过对82名糖尿病患者进行为期12个月（其中30名患者为期24个月）的高胰岛素血症测试，研究了磺胺类药物的长期影响。对于那些仅通过节食（单独或与双胍类药物联合使用）治疗的肥胖糖尿病患者，高胰岛素血症会自行减轻，血糖变化情况也是如此，尽管仍存在一些不同步性；而对于那些接受磺胺类药物治疗（单独或与其他治疗方法联合使用）的糖尿病患者，胰岛素血症曲线几乎没有改变。
