Moinade S, Gaillard G, Champeyroux J, Doly M, Glanddier Y, Dupuy-Cordez A
Pathol Biol (Paris). 1978 May-Jun;26(5):241-4.
The long-term effects of sulfonamides were studied by means of hyperinsulinemia tests in 82 diabetics over a period of 12 months (24 months for 30 of them). Whereas for those (obese) diabetes whose only treatment was dieting--alone or combined with biguanides--hyperinsulinemia attenuates itself as do also variations in glycemia, although some asynchronism remains, in those diabetics treated with sulfonamides--alone or in combination with other treatments--the insulinemia curve is hardly modified.
通过对82名糖尿病患者进行为期12个月（其中30名患者为期24个月）的高胰岛素血症测试，研究了磺胺类药物的长期影响。对于那些仅通过节食（单独或与双胍类药物联合使用）治疗的（肥胖）糖尿病患者，高胰岛素血症会自行减轻，血糖变化情况也是如此，尽管仍存在一些不同步现象；而对于那些单独使用或与其他治疗方法联合使用磺胺类药物治疗的糖尿病患者，胰岛素血症曲线几乎没有变化。
