外周血管疾病指标与冠心病患者阻塞血管数的关系。

Association between peripheral vascular disease indexes and the numbers of vessels obstructed in patients with coronary artery disease.

机构信息

Department of Internal Medicine, Second Section of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.

出版信息

Am J Med Sci. 2012 Jan;343(1):52-5. doi: 10.1097/MAJ.0b013e31821fec80.

DOI:10.1097/MAJ.0b013e31821fec80

PMID:21709534

Abstract

INTRODUCTION

The numbers of vessels obstructed in patients with coronary artery disease (CAD) is an important prognostic factor. Pulse wave velocity (PWV), ankle-brachial index (ABI) and the estimated glomerular filtration rate (eGFR) are associated with increasing CAD risks; however, the association between the numbers of vessels obstructed and PWV, ABI and eGFR is not clear.

METHODS

PWV, ABI and eGFR of 58 patients underwent coronary angiography for angina pectoris and acute coronary syndrome were measured. The variables that may be related to the number of vessels involved were analyzed using univariate linear regression followed by stepwise multivariate linear regression to determine the best-fit model.

RESULTS

The average PWV, ABI and eGFR were 1523 ± 281 cm/sec, 1.16 ± 0.06 and 76.0 ± 16.7 mL/min/1.73 m(2) for patients with no CAD; 1496 ± 230 cm/sec, 1.14 ± 0.09 and 82.3 ± 12.4 mL/min/1.73 m(2) for 1-vessel CAD; 1733 ± 298 cm/sec, 1.07 ± 0.17 and 63.0 ± 26.3 mL/min/1.73 m(2) for 2-vessel CAD and 1996 ± 664 cm/sec, 0.99 ± 0.19 and 56.2 ± 27.3 mL/min/1.73 m(2) for 3-vessel CAD. Age, diabetes, hypertension, pulse pressure, serum creatinine, eGFR, ABI and PWV were correlated with the numbers of vessel obstructed in univariate regression. In stepwise multivariate linear regression, diabetes, PWV and ABI was independently linked to the numbers of vessels obstructed (P=0.021, 0.004 and 0.025).

CONCLUSION

Noninvasive indexes for atherosclerotic vascular disease including PWV and ABI are linked to the number of vessels obstructed in patients with CAD.

摘要

简介

在患有冠状动脉疾病 (CAD) 的患者中，阻塞血管的数量是一个重要的预后因素。脉搏波速度 (PWV)、踝臂指数 (ABI) 和估算的肾小球滤过率 (eGFR) 与 CAD 风险的增加相关;然而，阻塞血管的数量与 PWV、ABI 和 eGFR 之间的关系尚不清楚。

方法

测量了 58 例因心绞痛和急性冠脉综合征而行冠状动脉造影的患者的 PWV、ABI 和 eGFR。使用单变量线性回归分析可能与受累血管数量相关的变量，然后进行逐步多变量线性回归，以确定最佳拟合模型。

结果

无 CAD 患者的平均 PWV、ABI 和 eGFR 分别为 1523±281cm/sec、1.16±0.06 和 76.0±16.7mL/min/1.73m(2);1 支血管 CAD 患者的平均 PWV、ABI 和 eGFR 分别为 1496±230cm/sec、1.14±0.09 和 82.3±12.4mL/min/1.73m(2);2 支血管 CAD 患者的平均 PWV、ABI 和 eGFR 分别为 1733±298cm/sec、1.07±0.17 和 63.0±26.3mL/min/1.73m(2);3 支血管 CAD 患者的平均 PWV、ABI 和 eGFR 分别为 1996±664cm/sec、0.99±0.19 和 56.2±27.3mL/min/1.73m(2)。年龄、糖尿病、高血压、脉压、血清肌酐、eGFR、ABI 和 PWV 与单变量回归中的血管阻塞数量相关。在逐步多变量线性回归中，糖尿病、PWV 和 ABI 与血管阻塞数量独立相关(P=0.021、0.004 和 0.025)。