Nat Genet. 2011 Jun 28;43(7):616-7. doi: 10.1038/ng.870.
Transcription of genomic loci containing protein-coding genes often yields not only cognate mRNAs but also assorted non-coding RNAs (ncRNAs), which typically map in the vicinity of transcription start sites. A new study demonstrates that far from being random byproducts of gene expression, many long ncRNAs (lncRNAs) are synthesized in a coordinate fashion and control important cellular processes, such as survival in the face of DNA damage.
转录基因组基因编码区不仅产生同源的 mRNA，还产生各种非编码 RNA（ncRNA），这些 ncRNA 通常定位于转录起始位点附近。一项新的研究表明，许多长非编码 RNA（lncRNA）并非基因表达的随机副产物，它们是以协调的方式合成的，并控制着重要的细胞过程，如在面对 DNA 损伤时的存活。
