长链非编码 RNA 的广泛作用。
The long reach of noncoding RNAs.
出版信息
Nat Genet. 2011 Jun 28;43(7):616-7. doi: 10.1038/ng.870.
Abstract
Transcription of genomic loci containing protein-coding genes often yields not only cognate mRNAs but also assorted non-coding RNAs (ncRNAs), which typically map in the vicinity of transcription start sites. A new study demonstrates that far from being random byproducts of gene expression, many long ncRNAs (lncRNAs) are synthesized in a coordinate fashion and control important cellular processes, such as survival in the face of DNA damage.
摘要
转录基因组基因编码区不仅产生同源的 mRNA，还产生各种非编码 RNA（ncRNA），这些 ncRNA 通常定位于转录起始位点附近。一项新的研究表明，许多长非编码 RNA（lncRNA）并非基因表达的随机副产物，它们是以协调的方式合成的，并控制着重要的细胞过程，如在面对 DNA 损伤时的存活。
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