非编码RNA：哺乳动物转录机制的调控因子
Noncoding RNAs: Regulators of the Mammalian Transcription Machinery.
作者信息
Eidem Tess M, Kugel Jennifer F, Goodrich James A
机构信息
Department of Chemistry and Biochemistry, University of Colorado, 596 UCB, Boulder, CO 80309-0596, USA.
Department of Chemistry and Biochemistry, University of Colorado, 596 UCB, Boulder, CO 80309-0596, USA.
出版信息
J Mol Biol. 2016 Jun 19;428(12):2652-2659. doi: 10.1016/j.jmb.2016.02.019. Epub 2016 Feb 23.
Abstract
Transcription by RNA polymerase II (Pol II) is required to produce mRNAs and some noncoding RNAs (ncRNAs) within mammalian cells. This coordinated process is precisely regulated by multiple factors, including many recently discovered ncRNAs. In this perspective, we will discuss newly identified ncRNAs that facilitate DNA looping, regulate transcription factor binding, mediate promoter-proximal pausing of Pol II, and/or interact with Pol II to modulate transcription. Moreover, we will discuss new roles for ncRNAs, as well as a novel Pol II RNA-dependent RNA polymerase activity that regulates an ncRNA inhibitor of transcription. As the multifaceted nature of ncRNAs continues to be revealed, we believe that many more ncRNA species and functions will be discovered.
摘要
在哺乳动物细胞内，RNA聚合酶II（Pol II）转录是产生信使核糖核酸（mRNA）和一些非编码核糖核酸（ncRNA）所必需的。这一协调过程受到多种因素的精确调控，其中包括许多最近发现的ncRNA。从这个角度出发，我们将讨论新发现的ncRNA，它们促进DNA环化、调节转录因子结合、介导Pol II在启动子近端的暂停，和/或与Pol II相互作用以调节转录。此外，我们还将讨论ncRNA的新作用，以及一种调节ncRNA转录抑制剂的新型Pol II RNA依赖性RNA聚合酶活性。随着ncRNA多方面的性质不断被揭示，我们相信将会发现更多种类的ncRNA及其功能。
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