Pettinato G, Manivel J C, De Rosa G, Petrella G, Jaszcz W
Department of Pathology, Second Medical School, University of Naples, Italy.
Mod Pathol. 1990 Jul;3(4):479-87.
Twenty examples of angiomatoid malignant fibrous histiocytoma (AMFH) were studied. Patients ranged in age from 3 mo to 42 yr, with a mean of 13.4 yr (median 10.5 yr). There were 12 males and eight females. Tumors occurred in the upper extremities in eight cases, lower extremities in 10 cases, and one case each in the buttock and neck. Five patients had local recurrence from 5 to 18 mo after initial surgery, and one patient developed regional lymph node metastases and eventually died of disease. Eight of nine patients with follow-up information were alive from 11 to 31 mo after the diagnosis. Preoperative fine needle aspiration cytology performed in two patients showed features that suggested the correct diagnosis. Ultrastructural and immunohistochemical studies demonstrated findings consistent with a fibroblastic-histiocytic nature of the neoplasm and failed to detect endothelial differentiation of the tumor cells. Flow cytometric analysis performed in six cases, including three recurrent tumors, revealed a DNA diploid pattern in all instances. AMFH appears to be a distinctive low grade sarcoma in the spectrum of malignant fibrous histiocytoma.
对20例血管瘤样恶性纤维组织细胞瘤（AMFH）进行了研究。患者年龄从3个月至42岁不等，平均年龄为13.4岁（中位数为10.5岁）。男性12例，女性8例。肿瘤发生在上肢8例，下肢10例，臀部和颈部各1例。5例患者在初次手术后5至18个月出现局部复发，1例患者发生区域淋巴结转移，最终死于该疾病。9例有随访信息的患者中，8例在诊断后11至31个月存活。2例患者术前细针穿刺细胞学检查显示的特征提示了正确诊断。超微结构和免疫组织化学研究显示的结果与肿瘤的成纤维细胞 - 组织细胞性质一致，未检测到肿瘤细胞的内皮分化。对6例病例进行了流式细胞术分析，其中包括3例复发性肿瘤，所有病例均显示DNA二倍体模式。AMFH似乎是恶性纤维组织细胞瘤谱系中一种独特的低级别肉瘤。
