Changzheng Hospital, Second Military Medical University, Shanghai, 200433, China.
Cancer Causes Control. 2011 Oct;22(10):1355-63. doi: 10.1007/s10552-011-9808-6. Epub 2011 Jun 28.
The pathogenesis of primary brain tumors may be related to immune response. Prior studies have shown a strong association between allergy and glioma; however, so far no significant association has been established between allergy and meningioma. Here, we conducted a meta-analysis of published studies to investigate the association of meningioma with the overall and specific allergic conditions.
PubMed, EMBASE database, and Cochrane Library were searched for pertinent citations published between January 1979 and October 2009. We used the following searching strategy (brain tumor [Text Word] OR meningioma [Text Word]) AND (allergy [Text Word] OR atopy [Text Word] OR asthma [Text Word] OR eczema [Text Word] OR hay fever [Text Word]) to search for relevant studies. Random effect model was used to estimate the association between allergic conditions and meningioma.
A total of 7 studies (5 case-control studies and 2 cohort studies) were included in the analysis, involving 54,391 participants, of whom 2,656 had meningioma. When compared to non-allergic conditions, the pooled odds ratio (OR) with any allergic conditions for meningioma was 0.91 (95% CI: 0.79-1.04, p = 0.163), suggesting that there is no significant association between meningioma and allergic conditions. Interestingly, further analysis showed that eczema had significantly inverse association with meningioma (OR, 0.75; 95% CI: 0.65-0.87, p < 0.05). On the other hand, no significant association was found for asthma (OR, 0.88; 95% CI: 0.75-1.04, p = 0.126) and hay fever (OR, 0.90; 95% CI: 0.79-1.03, p = 0.137).
In conclusion, there was a significantly negative association between eczema and meningioma, suggesting that eczema may reduce the risk of meningioma. Although it was not statistically significant association between meningioma and other specific allergic conditions such as asthma and hay fever, further studies with large sample size may be needed to determine its relationship.
原发性脑肿瘤的发病机制可能与免疫反应有关。先前的研究表明过敏与神经胶质瘤之间存在很强的关联；然而，到目前为止，还没有确立过敏与脑膜瘤之间存在显著关联。在这里，我们对已发表的研究进行了荟萃分析，以调查脑膜瘤与总体和特定过敏状况之间的关系。
检索 1979 年 1 月至 2009 年 10 月期间发表的相关文献，使用以下检索策略（脑肿瘤 [文本词] 或脑膜瘤 [文本词]）和（过敏 [文本词] 或特应性 [文本词] 或哮喘 [文本词] 或湿疹 [文本词] 或花粉热 [文本词]）搜索相关研究。使用随机效应模型估计过敏状况与脑膜瘤之间的关联。
共纳入 7 项研究（5 项病例对照研究和 2 项队列研究），共涉及 54391 名参与者，其中 2656 人患有脑膜瘤。与非过敏状况相比，脑膜瘤合并任何过敏状况的合并优势比（OR）为 0.91（95%CI：0.79-1.04，p=0.163），表明脑膜瘤与过敏状况之间无显著关联。有趣的是，进一步分析表明，湿疹与脑膜瘤呈显著负相关（OR，0.75；95%CI：0.65-0.87，p<0.05）。另一方面，哮喘（OR，0.88；95%CI：0.75-1.04，p=0.126）和花粉热（OR，0.90；95%CI：0.79-1.03，p=0.137）与脑膜瘤之间无显著关联。
总之，湿疹与脑膜瘤之间存在显著负相关，提示湿疹可能降低脑膜瘤的发病风险。尽管脑膜瘤与其他特定过敏状况（如哮喘和花粉热）之间没有统计学上的显著关联，但可能需要进一步进行更大样本量的研究来确定它们之间的关系。
