Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, China.
Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Sci Rep. 2017 Jan 10;7:40333. doi: 10.1038/srep40333.
Meningiomas are the most common brain tumours; however, little is known regarding their aetiology. The data are inconsistent concerning atopic disease and the risk of developing meningioma. Thus, we conducted a meta-analysis to investigate the association between allergic conditions and the risk of developing meningioma. A systematic literature search was conducted using PubMed and Web of SCI from Jan 1979 to Feb 2016. Two investigators independently selected the relevant articles according to the inclusion criteria. Eight case-control studies and 2 cohort studies were included in the final analysis, comprising 5,679 meningioma cases and 55,621 control subjects. Compared with no history of allergy, the pooled odds ratio (OR) for allergic conditions was 0.81 (0.70-0.94) for meningioma in a random-effects meta-analysis. Inverse correlations of meningioma occurrence were also identified for asthma and eczema, in which the pooled ORs were 0.78 (0.70-0.86) and 0.78 (0.69-0.87), respectively. A reduced risk of meningioma occurrence was identified in hay fever; however, the association was weak (0.88, 95% CI = 0.78-0.99). The source of this heterogeneity could be the various confounding variables in individual studies. Overall, the current meta-analysis indicated that allergy reduced the risk of developing meningiomas. Large cohort studies are required to investigate this relationship.
脑膜瘤是最常见的脑肿瘤；然而，关于其病因知之甚少。特应性疾病与脑膜瘤发病风险之间的数据并不一致。因此，我们进行了一项荟萃分析，以调查过敏与脑膜瘤发病风险之间的关系。使用 PubMed 和 Web of SCI 从 1979 年 1 月至 2016 年 2 月进行了系统的文献检索。两名调查员根据纳入标准独立选择了相关文章。最终分析包括 8 项病例对照研究和 2 项队列研究，共包含 5679 例脑膜瘤病例和 55621 例对照。与无过敏史相比，过敏性疾病的汇总比值比（OR）为 0.81（0.70-0.94）。在随机效应荟萃分析中，哮喘和湿疹也与脑膜瘤发生呈负相关，汇总 OR 分别为 0.78（0.70-0.86）和 0.78（0.69-0.87）。花粉症与脑膜瘤发生的风险降低相关，但相关性较弱（0.88，95%CI=0.78-0.99）。这种异质性的来源可能是个别研究中的各种混杂变量。总体而言，目前的荟萃分析表明过敏降低了发生脑膜瘤的风险。需要进行大型队列研究来进一步调查这种关系。
