Neuro-Oncology Unit, Davidoff Cancer Center, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.
Department of Gastroenterology, Hadassah University Hospital - Ein Kerem, Jerusalem, Israel.
BMC Cancer. 2020 Aug 20;20(1):786. doi: 10.1186/s12885-020-07292-4.
Meningiomas are the most common primary central nervous system tumors. Potential risk factors include obesity, height, history of allergy/atopy, and autoimmune diseases, but findings are conflicting. This study sought to assess the role of the different risk factors in the development of meningioma in adolescents/young adults.
The cohort included 2,035,915 Jewish men and women who had undergone compulsory physical examination between 1967 and 2011, at age 16 to 19 years, prior to and independent of actual military enlistment. To determine the incidence of meningioma, the military database was matched with the Israel National Cancer Registry. Cox proportional hazard models were used to estimate the hazard ratios for meningioma according to sex, body mass index (BMI), height, and history of allergic or autoimmune disease.
A total of 480 subjects (328 females) were diagnosed with meningioma during a follow-up of 40,304,078 person-years. Median age at diagnosis was 42.1 ± 9.4 years (range 17.4-62.6). On univariate analysis, female sex (p < 0.01) and height (p < 0.01) were associated with risk of meningioma. When the data were stratified by sex, height remained a significant factor only in men. Spline analysis of the male subjects showed that a height of 1.62 m was associated with a minimum disease risk and a height of 1.85+ meters, with a significant risk.
This large population study showed that sex and adolescent height in males (> 1.85 m) were associated with an increased risk of meningioma in adulthood.
脑膜瘤是最常见的原发性中枢神经系统肿瘤。潜在的危险因素包括肥胖、身高、过敏/特应病史和自身免疫性疾病，但研究结果存在冲突。本研究旨在评估不同危险因素在青少年/年轻成人脑膜瘤发病中的作用。
该队列包括 2035915 名犹太男女，他们在 1967 年至 2011 年间，在 16 至 19 岁时接受了强制性体检，这与实际入伍无关。为了确定脑膜瘤的发病率，军队数据库与以色列国家癌症登记处相匹配。使用 Cox 比例风险模型根据性别、体重指数 (BMI)、身高和过敏或自身免疫性疾病史来估计脑膜瘤的风险比。
在 40304078 人年的随访中，共有 480 名患者（328 名女性）被诊断患有脑膜瘤。诊断时的中位年龄为 42.1±9.4 岁（范围 17.4-62.6）。单因素分析显示，女性（p<0.01）和身高（p<0.01）与脑膜瘤的风险相关。当按性别对数据进行分层时，只有男性的身高仍然是一个重要因素。对男性受试者的样条分析显示，身高 1.62 米与疾病风险最小相关，身高 1.85 米以上与显著风险相关。
这项大型人群研究表明，女性和男性青少年时的身高（>1.85 米）与成年后患脑膜瘤的风险增加有关。
