Division of Chemical Biology & Biotechnology, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore.
Nat Prod Rep. 2010 Apr;27(4):499-528. doi: 10.1039/b908165h. Epub 2010 Feb 18.
The review highlights the recent progress on the elucidation of the biosynthetic mechanism of enediyne natural products. A large body of knowledge has been gathered from the genetic, biochemical and structural studies since the sequencing of the first two enediyne gene clusters in 2002. Primary attention is devoted to the novel pathways and enzymes in the biosynthesis of the enediyne warhead as well as the peripheral moieties.
该综述强调了阐明烯二炔天然产物生物合成机制的最新进展。自 2002 年首次测序两个烯二炔基因簇以来，通过遗传、生化和结构研究积累了大量知识。主要关注烯二炔弹头以及周边部分生物合成中的新途径和酶。
