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斑秃与白癜风的一种罕见共定位现象。

An extraordinary colocalization of alopecia areata and vitiligo.

作者信息

Ramot Yuval, Thomaidou Elena, Mali Alexander, Zlotogorski Abraham

机构信息

Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

出版信息

Int J Trichology. 2010 Jul;2(2):108-9. doi: 10.4103/0974-7753.77522.

DOI:10.4103/0974-7753.77522
PMID:21712899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3107954/
Abstract

Although the association of alopecia areata (AA) and vitiligo occurring in the same patient has been frequently reported in the literature, the colocalization of AA and vitiligo is very rare. We report for the first time an adult patient with anatomic concurrence of AA and vitiligo on the scalp. Even though both AA and vitiligo are thought to have the same underlying pathophysiologic mechanisms, the striking rarity of their colocalization challenges this postulated common pathogenesis, and raises the question if autoimmunity is responsible for only a fraction of AA or vitiligo.

摘要

尽管斑秃(AA)和白癜风在同一患者中并发的情况在文献中已有频繁报道,但AA和白癜风在解剖学上的共定位却非常罕见。我们首次报告了一名成年患者,其头皮上同时出现了AA和白癜风。尽管人们认为AA和白癜风具有相同的潜在病理生理机制,但它们共定位现象极为罕见,这对这种假定的共同发病机制提出了挑战,并引发了自身免疫是否仅导致部分AA或白癜风病例的疑问。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf79/3107954/629f66a847a4/IJT-2-108-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf79/3107954/629f66a847a4/IJT-2-108-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf79/3107954/629f66a847a4/IJT-2-108-g001.jpg

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Alopecia Areata as a Manifestation of Systemic Lymphoma: Report of Two Cases.斑秃作为系统性淋巴瘤的一种表现:两例报告
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Renbök phenomenon in an alopecia areata patient with psoriasis.一名患有银屑病的斑秃患者出现的雷诺现象。

本文引用的文献

1
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.斑秃的全基因组关联研究提示固有免疫和适应性免疫均参与其中。
Nature. 2010 Jul 1;466(7302):113-7. doi: 10.1038/nature09114.
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Epidemiology of vitiligo, associated autoimmune diseases and audiological abnormalities: Ankara study of 80 patients in Turkey.白癜风的流行病学、相关自身免疫性疾病和听力异常:土耳其安卡拉 80 例患者的研究。
J Eur Acad Dermatol Venereol. 2010 Oct;24(10):1144-50. doi: 10.1111/j.1468-3083.2010.03605.x.
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Int J Trichology. 2013 Oct;5(4):194-5. doi: 10.4103/0974-7753.130397.
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Vitiligo and alopecia areata: apples and oranges?白癜风和斑秃:苹果和橙子?
Exp Dermatol. 2013 Dec;22(12):785-9. doi: 10.1111/exd.12264.
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Colocalization of vitiligo and alopecia areata: coincidence or consequence?白癜风与斑秃的共定位:巧合还是因果关系?
Int J Trichology. 2013 Jan;5(1):50-2. doi: 10.4103/0974-7753.114705.
7
T-cell reconstitution after thymus xenotransplantation induces hair depigmentation and loss.胸腺异种移植后 T 细胞重建可导致毛发脱色和丧失。
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斑秃更新:第一部分。临床表现、组织病理学和发病机制。
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4
An unusual anatomical colocalization of alopecia areata and vitiligo in a child, and improvement during treatment with topical prostaglandin E2.一名儿童斑秃与白癜风的罕见解剖学共定位,以及外用前列腺素E2治疗期间的病情改善。
Clin Exp Dermatol. 2009 Dec;34(8):e1010-1. doi: 10.1111/j.1365-2230.2009.03677.x.
5
Lymphocytes, neuropeptides, and genes involved in alopecia areata.斑秃中涉及的淋巴细胞、神经肽和基因。
J Clin Invest. 2007 Aug;117(8):2019-27. doi: 10.1172/JCI31942.
6
Autoimmunity as an aetiological factor in vitiligo.自身免疫作为白癜风的一个病因因素。
J Eur Acad Dermatol Venereol. 2007 Aug;21(7):865-76. doi: 10.1111/j.1468-3083.2007.02228.x.
7
Vitiligo: a part of a systemic autoimmune process.白癜风:系统性自身免疫过程的一部分。
Indian J Dermatol Venereol Leprol. 2007 May-Jun;73(3):162-5. doi: 10.4103/0378-6323.32710.
8
Clinical profiles of vitiligo in China: an analysis of 3742 patients.中国白癜风临床特征:3742例患者分析
Clin Exp Dermatol. 2005 Jul;30(4):327-31. doi: 10.1111/j.1365-2230.2005.01813.x.
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Alopecia areata: autoimmune basis of hair loss.斑秃:脱发的自身免疫基础。
Eur J Dermatol. 2004 Nov-Dec;14(6):364-70.
10
ALOPECIA AREATA. AN EVALUATION OF 736 PATIENTS.斑秃。对736例患者的评估。
Arch Dermatol. 1963 Sep;88:290-7. doi: 10.1001/archderm.1963.01590210048007.