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用蜂蜜对斯普拉格-道利大鼠全层烧伤创面细菌污染愈合情况的评估

Evaluations of bacterial contaminated full thickness burn wound healing in Sprague Dawley rats Treated with Tualang honey.

作者信息

Sukur Salmi Mohamed, Halim Ahmad Sukari, Singh Kirnpal Kaur Banga

机构信息

Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia, Malaysia.

出版信息

Indian J Plast Surg. 2011 Jan;44(1):112-7. doi: 10.4103/0970-0358.81459.

DOI:10.4103/0970-0358.81459
PMID:21713196
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3111101/
Abstract

AIM

The effect of Tualang honey on wound healing in bacterial contaminated full-thickness burn wounds was evaluated in 36 male Sprague Dawley rats.

MATERIALS AND METHODS

The rats were randomly divided into three groups (n = 12/group). Three full-thickness burn wounds were created on each rat. Each group of rats was inoculated with a different organism in the burn wounds: Group A was inoculated with Pseudomonas aeruginosa, Group B was inoculated with Klebsiella pneumoniae and Group C was inoculated with Acinetobacter baumannii. One wound on each rat was dressed with either Tualang honey, Chitosan gel or Hydrofibre silver. Each wound size was measured on day 3, 6, 9, 12, 15, 18 and 21 of the study.

RESULTS

The mean wound size of the Tualang honey-treated wounds was not statistically different than that of the Chitosan gel or Hydrofibre silver-treated wounds when the wounds were compared throughout the entire experiment (P > 0.05). However, comparing the mean wound size on day 21 alone revealed that the Tualang honey-treated wounds were smaller in comparison to that of the Chitosan gel and Hydrofibre silver-treated groups.

CONCLUSIONS

This study shows that topical application of Tualang honey on burn wounds contaminated with P. aeruginosa and A. baumannii gave the fastest rate of healing compared with other treatments.

摘要

目的

在36只雄性斯普拉格-道利大鼠中评估了多花蜂蜜对细菌污染的全层烧伤创面愈合的影响。

材料与方法

将大鼠随机分为三组（每组n = 12）。每只大鼠制造三个全层烧伤创面。每组大鼠在烧伤创面接种不同的细菌：A组接种铜绿假单胞菌，B组接种肺炎克雷伯菌，C组接种鲍曼不动杆菌。每只大鼠的一个创面用多花蜂蜜、壳聚糖凝胶或水凝胶银敷料覆盖。在研究的第3、6、9、12、15、18和21天测量每个创面的大小。

结果

在整个实验过程中比较创面时，多花蜂蜜处理的创面的平均大小与壳聚糖凝胶或水凝胶银处理的创面相比无统计学差异（P>0.05）。然而，仅比较第21天的平均创面大小发现，与壳聚糖凝胶和水凝胶银处理组相比，多花蜂蜜处理的创面更小。

结论

本研究表明，与其他治疗方法相比，在被铜绿假单胞菌和鲍曼不动杆菌污染的烧伤创面上局部应用多花蜂蜜可实现最快的愈合速度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b88e/3111101/f7bcbca2b42b/IJPS-44-112-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b88e/3111101/0e0cae21c9f1/IJPS-44-112-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b88e/3111101/865b7e44b61d/IJPS-44-112-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b88e/3111101/f7bcbca2b42b/IJPS-44-112-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b88e/3111101/0e0cae21c9f1/IJPS-44-112-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b88e/3111101/865b7e44b61d/IJPS-44-112-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b88e/3111101/f7bcbca2b42b/IJPS-44-112-g006.jpg

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