Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, UK.
Adv Exp Med Biol. 2011;716:235-69. doi: 10.1007/978-1-4419-9533-9_13.
Mast cells play an important role in the lung in both health and disease. Their primary role is to initiate an appropriate program of inflammation and repair in response to tissue damage initiated by a variety of diverse stimuli. They are important for host immunity against bacterial infection and potentially in the host immune response to non small cell lung cancer. In situations of ongoing tissue damage, the sustained release of numerous pro-inflammatory mediators, proteases and cytokines, contributes to the pathophysiology of lung diseases such as asthma and interstitial lung disease. A key goal is the development of treatments which attenuate adverse mast cell function when administered chronically to humans in vivo. Such therapies may offer a novel approach to the treatment of many life-threatening diseases.
肥大细胞在肺部的健康和疾病中都起着重要作用。它们的主要作用是在各种不同的刺激物引发组织损伤时，启动适当的炎症和修复程序。它们对于宿主对抗细菌感染的免疫以及对非小细胞肺癌的宿主免疫反应非常重要。在持续的组织损伤情况下，大量促炎介质、蛋白酶和细胞因子的持续释放，导致哮喘和间质性肺疾病等肺部疾病的病理生理学发生变化。一个关键目标是开发出能够在体内慢性给予人类时减轻不良肥大细胞功能的治疗方法。这种治疗方法可能为许多危及生命的疾病的治疗提供新的途径。
