Rosenbaum R S, Carson N, Abraham N, Bowles B, Kwan D, Köhler S, Svoboda E, Levine B, Richards B
Department of Psychology, York University, Toronto, Canada.
Neurocase. 2011 Oct;17(5):394-409. doi: 10.1080/13554794.2010.532138. Epub 2011 Jun 30.
A current debate in the literature is whether all declarative memories and associated memory processes rely on the same neural substrate. Here, we show that H.C., a developmental amnesic person with selective bilateral hippocampal volume loss, has a mild deficit in personal episodic memory, and a more pronounced deficit in public event memory; semantic memory for personal and general knowledge was unimpaired. This was accompanied by a subtle difference in impairment between recollection and familiarity on lab-based tests of recognition memory. Strikingly, H.C.'s recognition did not benefit from a levels-of-processing manipulation. Thus, not all types of declarative memory and related processes can exist independently of the hippocampus even if it is damaged early in life.
文献中当前的一个争论是，所有陈述性记忆及相关记忆过程是否依赖于相同的神经基质。在此，我们表明，H.C.是一名患有发育性遗忘症的个体，双侧海马体选择性体积缺失，其个人情景记忆存在轻度缺陷，公共事件记忆缺陷更为明显；关于个人和一般知识的语义记忆未受损。这伴随着在基于实验室的识别记忆测试中，回忆和熟悉度受损方面的细微差异。引人注目的是，H.C.的识别并未从加工水平操纵中受益。因此，即使海马体在生命早期受损，并非所有类型的陈述性记忆及相关过程都能独立于海马体而存在。
