Muhammad Azami Nor Azila, Salleh Sharifah Azura, Neoh Hui-Min, Syed Zakaria Syed Zulkifli, Jamal Rahman
UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Malaysia.
BMC Res Notes. 2011 Jun 29;4:216. doi: 10.1186/1756-0500-4-216.
Dengue infection has been an important and serious public health concern in Malaysia ever since its first reported case here in 1902. Nevertheless, to our knowledge, no nationwide investigation has been carried out to determine the actual magnitude of dengue endemicity in the Malaysian population. In this study, we describe a cross sectional seroepidemiology study of dengue IgG seroprevalence in the Malaysian adult population.
From 1000 subjects (35-74 years old), 91.6% subjects were found to be dengue seropositive. Age is found to be a significant risk factor associated with dengue seroposivity, where the seroprevalence increased with every 10 year increase in age. Nevertheless, gender and ethnicity did not have an effect. Interestingly, there were similar seroprevalence rates between urban and rural samples, showing that dengue is presently not confined to urban areas in Malaysia.
High dengue IgG seropositivity found in the population is an indication that dengue might be endemic in Malaysia for a long time into the future. Public awareness, proper vector control and vigilant surveillance are critical to keep the infection rates low and to prevent outbreaks.
自1902年马来西亚首次报告登革热病例以来，登革热感染一直是该国重要且严重的公共卫生问题。然而，据我们所知，尚未开展全国性调查来确定马来西亚人群中登革热流行的实际规模。在本研究中，我们描述了一项针对马来西亚成年人群登革热IgG血清阳性率的横断面血清流行病学研究。
在1000名35至74岁的受试者中，91.6%的受试者被发现登革热血清呈阳性。年龄被发现是与登革热血清阳性相关的一个重要风险因素，血清阳性率随着年龄每增加10岁而上升。然而，性别和种族并无影响。有趣的是，城市和农村样本的血清阳性率相似，表明登革热目前在马来西亚并不局限于城市地区。
人群中高登革热IgG血清阳性表明登革热在马来西亚可能在未来很长一段时间内呈地方性流行。公众意识、适当的病媒控制和警惕的监测对于保持低感染率和预防疫情爆发至关重要。
