Prevention Research Center, Yale University School of Medicine, Griffin Hospital, 130 Division Street, 2nd Floor, Derby, Connecticut 06418, USA.
Nutr J. 2011 Jun 29;10:72. doi: 10.1186/1475-2891-10-72.
Dehydrated fruit and vegetable concentrates provide an accessible form of phytonutrient supplementation that may offer cardioprotective effects. This study assessed the effects of two blends of encapsulated juice powder concentrates (with and without added berry powders) on endothelial function in persons with metabolic syndrome, a risk factor for type 2 diabetes and cardiovascular disease.
Randomized, double blind, placebo controlled crossover clinical trial with three treatment arms. 64 adults with metabolic syndrome were enrolled and received 8-week sequences of each blend of the concentrates and placebo. The primary outcome measure was change in endothelial function (assessed as flow-mediated dilatation of the brachial artery) 2 hr after consuming a 75 g glucose load, after 8-weeks of daily consumption (sustained) or 2 hr after consumption of a single dose (acute). Secondary outcome measures included plasma glucose, serum insulin, serum lipids, and body weight.
No significant between-group differences in endothelial function with daily treatment for 8 weeks were seen. No other significant treatment effects were discerned in glucose, insulin, lipids, and weight.
Encapsulated fruit and vegetable juice powder concentrates did not alter insulin or glucose measures in this sample of adults with metabolic syndrome.
clinicaltrials.gov NCT01224743.
脱水水果和蔬菜浓缩物提供了一种易于获得的植物营养素补充形式，可能具有心脏保护作用。本研究评估了两种封装果汁粉浓缩物（含或不含添加的浆果粉）混合物对代谢综合征患者内皮功能的影响，代谢综合征是 2 型糖尿病和心血管疾病的风险因素。
这是一项随机、双盲、安慰剂对照的交叉临床试验，共有三个治疗组。共纳入 64 名代谢综合征患者，分别接受 8 周的浓缩物混合物和安慰剂治疗。主要结局测量指标是在摄入 75 克葡萄糖负荷后 2 小时，内皮功能（肱动脉血流介导的扩张）的变化，在每日持续摄入 8 周后或单次剂量摄入后 2 小时。次要结局测量指标包括血浆葡萄糖、血清胰岛素、血清脂质和体重。
在每日治疗 8 周后，各组之间的内皮功能无显著差异。在葡萄糖、胰岛素、脂质和体重方面，没有发现其他显著的治疗效果。
在代谢综合征的成年人样本中，封装的水果和蔬菜汁粉浓缩物并没有改变胰岛素或葡萄糖的指标。
clinicaltrials.gov NCT01224743。
