对沙特阿拉伯东部一家三级医院产前保健诊所的孕妇进行沙眼衣原体和淋病奈瑟菌感染筛查。
Screening of pregnant women attending the antenatal care clinic of a tertiary hospital in eastern Saudi Arabia for Chlamydia trachomatis and Neisseria gonorrhoeae infections.
作者信息
Alzahrani Alhusain J, Obeid Obeid E, Hassan Manal I, Almulhim Abdalaziz A
机构信息
Department of Microbiology, College of Medicine, Dammam University, Kingdom of Saudi Arabia.
出版信息
Indian J Sex Transm Dis AIDS. 2010 Jul;31(2):81-6. doi: 10.4103/0253-7184.74976.
INRODUCTION
Of the "top ten" sexually transmitted infections, Chlamydia trachomatis and Neisseria gonorrhoeae are ranked second and fifth, respectively, worldwide.
AIM
The aim of this study was to screen the pregnant women for C. trachomatis and N. gonorrhoeae infections and to detect antimicrobial resistance pattern of N. gonorrhoeae.
MATERIALS AND METHODS
This study was a prospective, hospital-based analysis of a random sample of pregnant women visiting the antenatal clinic of a tertiary hospital in eastern Saudi Arabia. Endocervical and high vaginal swabs were collected both from pregnant women and female patients attending gynecology clinic with lower genital tract infection (control group). C. trachomatis antigen was detected using enzyme-linked immunosorbent assay (ELISA). N. gonorrhoeae was detected by culture and identification of isolates, and antimicrobial susceptibility testing was performed. Statistical Package for Social Sciences (SPSS) version 13.0 and Chi-square test were used for statistical analysis.
RESULTS
C. trachomatis antigen was detected in 10.5% (10/95) and 34.4% (35/102) of pregnant women and control group, respectively (P < 0.001). The isolation rate of N. gonorrhoeae among pregnant women was 0.0% compared to 7.8% (8/102) among the control group (P < 0.01). N. gonorrhoeae were resistant to penicillin (62.5%), tetracycline (50%), ampicillin (25%), amoxycillin-clavulinic acid (25%) and ciprofloxacin (37.5%), while they were susceptible to cefepime, ceftriaxone, ceftazidime, spectinomycin, and cefuroxime.
CONCLUSION
Screening of pregnant women for C. trachomatis infection should be included in the antenatal care in this area. The detection rate of both organisms among the control group highlights the importance of preventive strategies. Certain antibiotics previously used in treating gonorrhea are no longer effective.
引言
在“十大”性传播感染中，沙眼衣原体和淋病奈瑟菌在全球分别位列第二和第五。
目的
本研究旨在对孕妇进行沙眼衣原体和淋病奈瑟菌感染筛查，并检测淋病奈瑟菌的抗菌耐药模式。
材料与方法
本研究是一项基于医院的前瞻性分析，对沙特阿拉伯东部一家三级医院产前门诊的孕妇随机样本进行研究。从孕妇以及患有下生殖道感染的妇科门诊女性患者（对照组）中采集宫颈管拭子和高阴道拭子。使用酶联免疫吸附测定（ELISA）检测沙眼衣原体抗原。通过培养和分离株鉴定检测淋病奈瑟菌，并进行抗菌药敏试验。使用社会科学统计软件包（SPSS）13.0版和卡方检验进行统计分析。
结果
孕妇组和对照组中沙眼衣原体抗原检测率分别为10.5%（10/95）和34.4%（35/102）（P<0.001）。孕妇中淋病奈瑟菌的分离率为0.0%，而对照组为7.8%（8/102）（P<0.01）。淋病奈瑟菌对青霉素耐药率为62.5%，四环素为50%，氨苄西林为25%，阿莫西林 - 克拉维酸为25%，环丙沙星为37.5%，而对头孢吡肟、头孢曲松、头孢他啶、壮观霉素和头孢呋辛敏感。
结论
该地区产前护理应包括对孕妇进行沙眼衣原体感染筛查。对照组中这两种病原体的检出率凸显了预防策略的重要性。某些先前用于治疗淋病的抗生素已不再有效。
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