Dobrynina O V, Shatinina S Z, Archakov A I
Biull Eksp Biol Med. 1990 Jul;110(7):94-6.
Rat hepatocyte plasmatic membrane damages caused by the administration of tetrachloromethane of heliotrine was investigated. Phospholipid content in plasmatic membranes decreased. Heliotrine caused complete and CCL4 twofold inhibition of Na, K-ATPase. Intraperitoneal administration of egg yolk phosphatidylcholine liposomes had a reparative effect on the damaged membranes consisting in the restoration of phospholipid content and enzyme activities.
研究了由天芥菜碱或四氯化碳给药引起的大鼠肝细胞质膜损伤。质膜中的磷脂含量降低。天芥菜碱导致钠钾 - 三磷酸腺苷酶完全抑制,而四氯化碳导致其双重抑制。腹腔注射蛋黄磷脂酰胆碱脂质体对受损膜具有修复作用,包括磷脂含量和酶活性的恢复。