α-干扰素对肝硬化大鼠红细胞和肝细胞质膜的作用。

Effect of alpha-interferon on erythrocyte and hepatocyte plasma membranes derived from cirrhotic rats.

作者信息

Muriel P, Bolaños J, Barral J M, Torres G

机构信息

Departmento de Farmacologia y Toxicologia, Instituto Politecnico Nacional, México, D.F., México.

出版信息

Pharmacology. 1994 Jan;48(1):63-8. doi: 10.1159/000139163.

DOI:10.1159/000139163

PMID:8309989

Abstract

Interferons are recognized to inhibit collagen production. Since fibrosis has been associated with liver dysfunction, we investigated the effects of alpha-interferon on the function and lipid composition of hepatocyte and erythrocyte plasma membranes derived from CCl4-cirrhotic male Wistar rats. In both cell types, CCl4 decreased Na+/K+ and Ca(2+)-ATPase activity and increased the cholesterol to phospholipids (CH/PL) ratio (p < 0.05). Administration of interferon (80,000 IU/kg s.c. for 8 weeks) increased survival from 40 to 90%, and preserved normal ATPase activity and CH/PL ratio. Our results show that administration of alpha-interferon to CCl4-cirrhotic rats improves survival, and liver and erythrocyte membrane function and composition, probably as a result of its antifibrogenic effect.

摘要

干扰素被认为可抑制胶原蛋白的产生。由于纤维化与肝功能障碍有关，我们研究了α-干扰素对四氯化碳诱导肝硬化的雄性Wistar大鼠肝细胞和红细胞质膜功能及脂质组成的影响。在这两种细胞类型中，四氯化碳均降低了钠钾ATP酶和钙ATP酶的活性，并增加了胆固醇与磷脂（CH/PL）的比值（p < 0.05）。给予干扰素（80,000 IU/kg皮下注射，持续8周）可使存活率从40%提高到90%，并维持正常的ATP酶活性和CH/PL比值。我们的结果表明，给四氯化碳诱导肝硬化的大鼠施用α-干扰素可提高存活率，并改善肝脏和红细胞膜的功能及组成，这可能是其抗纤维化作用的结果。