Pan'kova T D, Timoshin S S
Biull Eksp Biol Med. 1990 Jul;110(7):96-8.
The role of opiate receptors on cell division in corneal epithelium during administration of dalargin was analysed. Naloxone injection/200 micrograms/kg/decreased MI two times, DNA-synthesis 1.4 times over 24 hours. Naloxone prevented dalargin effect on cell proliferation. Another testimonies of dalargin opiate-binding mitogenic effect were the results of the study with dalargin analogues. They are agonists of opiate receptors too. These drugs, as well as dalargin, in a dose 10 micrograms/kg increased DNA-synthesis 1.5 times, MI and MIK 2.2 times. It turned out, that the administration of another two analogues of dalargin, which are not ligands of opiate receptors, probably do not cause an adequate increase of DNA-synthesis and mitotic index.
分析了在给予达朗津期间阿片受体在角膜上皮细胞分裂中的作用。注射纳洛酮/200微克/千克/使有丝分裂指数在24小时内降低了两倍，DNA合成降低了1.4倍。纳洛酮可防止达朗津对细胞增殖的影响。关于达朗津阿片结合促有丝分裂作用的另一个证据是对达朗津类似物的研究结果。它们也是阿片受体激动剂。这些药物与达朗津一样，以10微克/千克的剂量可使DNA合成增加1.5倍，有丝分裂指数和中期分裂指数增加2.2倍。结果表明，另外两种不是阿片受体配体的达朗津类似物的给药可能不会引起DNA合成和有丝分裂指数的充分增加。
