Aleksandrovich A G, Zhdanova T F, Timoshin S S, Uchakina R V
Biull Eksp Biol Med. 1989 Aug;108(8):209-11.
Using autoradiographic study with 3H-thymidine and spectrofluorometric method the authors studied the influence of opioid receptors' ligands on the DNA synthesis in the stomach epithelium histamine content and the blood. Leu-encephalin, B-endorphin, dalargin, napoxone were administered intraperitoneally to male rats. The dose of injection was 0.1 ml per 100 g body weight. It was observed that B-endorphin and dalargin 1.5-1.6 fold increased the quantity of DNA-synthesised nuclei in the epithelium of fundal stomach section. Leu-encephalin and dalargin increased the histamine concentration in the stomach, at the same time dalargin caused a rapid decrease of histamine concentration in the blood. Naloxone also decreased histamine concentration in the stomach. The obtained results are being discussed in connection with dalargin therapy of ulcerous diseases.
作者使用³H-胸腺嘧啶放射自显影研究和荧光分光光度法，研究了阿片受体配体对胃上皮细胞DNA合成、组胺含量及血液的影响。将亮脑啡肽、β-内啡肽、达明和纳泊酮腹腔注射给雄性大鼠。注射剂量为每100克体重0.1毫升。观察到，β-内啡肽和达明使胃底部切片上皮细胞中DNA合成细胞核的数量增加了1.5 - 1.6倍。亮脑啡肽和达明增加了胃中的组胺浓度，同时达明导致血液中组胺浓度迅速下降。纳洛酮也降低了胃中的组胺浓度。结合达明治疗溃疡性疾病对所得结果进行了讨论。
