Sétáló G, Nakane P K
Endocrinol Exp. 1976;10(3):155-66.
The onset of hormone synthesis in the rat fetal pituitary gland was studied with the use of the peroxidase labelled antibody method. On the 16th day of fetal life, cells containing immunoreactive ACTH appeared in the primordial cell outgrowth of the Rathke's pouch. In some fetuses, also prolactin cells could be detected at the same developmental stage and these cells were present consistently on subsequent days. Differentiation of ACTH and prolactin cells was followed by onset of TSH, LH and GH synthesis on the 17th, 18th and 19th day of gestation, respectively.
采用过氧化物酶标记抗体法研究了大鼠胎儿垂体中激素合成的起始情况。在胎儿期第16天，含有免疫反应性促肾上腺皮质激素（ACTH）的细胞出现在拉特克囊的原始细胞增生中。在一些胎儿中，在相同发育阶段也可检测到催乳素细胞，且在随后几天这些细胞持续存在。促肾上腺皮质激素和催乳素细胞分化之后，促甲状腺激素（TSH）、促黄体生成素（LH）和生长激素（GH）的合成分别在妊娠第17天、18天和19天开始。
