Karkishchenko N N, Makliakov Iu S, Stradomskiĭ B V
Farmakol Toksikol. 1990 Jul-Aug;53(4):67-72.
The data on the neuro- and psychotropic effects of exo- and endogenous derivatives of pyrimidine are systematized. Uridine is characterized as an endogenous anxiolytic and antidepressant and thimidine as uridine antagonist. The given properties are probably determined by the binding of pyrimidine nucleosides to GABA, benzodiazepine and imipramine receptors as well as by their influence on the neuromediator systems. The involvement of the system of endogenous pyrimidines in the development of psychoneurological disturbances in man is shown.
嘧啶外源性和内源性衍生物的神经及精神作用的数据已被系统化整理。尿苷被描述为一种内源性抗焦虑和抗抑郁剂，而胸苷则是尿苷拮抗剂。这些特性可能是由嘧啶核苷与γ-氨基丁酸（GABA）、苯二氮䓬和丙咪嗪受体的结合以及它们对神经介质系统的影响所决定的。研究表明内源性嘧啶系统参与了人类精神神经障碍的发生发展。
