Akhundov R A, Voronina T A, Valdman A V
Acta Physiol Pharmacol Bulg. 1985;11(4):3-11.
This paper presents a review of literature data and results from investigations designed to determine the relation between structure, affinity to benzodiazepine receptors and pharmacological activity of possible endogenous ligands of benzodiazepine receptors and their electronic structural analogs. Structural variations of endogenous ligands of benzodiazepine receptors are substantiated to manifest themselves as active psychotropic drugs. On the basis of these considerations and experimental data, compounds with psychotropic activity and electronic structure, resembling that of "endogenous ligands" of benzodiazepine receptors, were developed.
本文综述了文献数据以及旨在确定苯二氮䓬受体可能的内源性配体及其电子结构类似物的结构、与苯二氮䓬受体的亲和力和药理活性之间关系的研究结果。苯二氮䓬受体内源性配体的结构变化被证实表现为活性精神药物。基于这些考虑和实验数据，开发出了具有精神活性且电子结构类似于苯二氮䓬受体“内源性配体”的化合物。
