肝豆状核变性患者肝细胞癌的射频消融治疗病例

Hepatocellular carcinoma in a case of Wilson's disease treated with radiofrequency ablation therapy.

作者信息

Ikegawa Shuntaro, Hiraoka Atsushi, Shimizu Yukou, Hidaka Satoshi, Tazuya Nayu, Ichiryu Misa, Nakahara Hiromasa, Tanabe Atsushi, Tanihira Tetsuya, Hasebe Aki, Miyamoto Yasunao, Ninomiya Tomoyuki, Hirooka Masashi, Kumagi Teru, Abe Masanori, Hiasa Yoichi, Onji Morikazu, Michitaka Kojiro

机构信息

Ehime Prefectural Central Hospital, Japan.

出版信息

Intern Med. 2011;50(13):1433-7. doi: 10.2169/internalmedicine.50.5203. Epub 2011 Jul 1.

DOI:10.2169/internalmedicine.50.5203

PMID:21720066

Abstract

A 37-year-old Japanese man was diagnosed with liver cirrhosis due to Wilson's disease in 2001 and treated with D-penicillamine. Thereafter, he was admitted to our hospital for further examination of a space occupying lesion in the liver. The patient was diagnosed with hepatocellular carcinoma (HCC) (7th segment, 2.5 cm in diameter) in May 2010 and treated with radiofrequency ablation therapy. Biopsy findings from a non-cancerous area revealed a fatty liver, though cirrhotic nodules were not found. Long-term treatment for Wilson's disease may improve hepatic fibrosis, and careful screening for HCC by abdominal imaging is needed in such cases.

摘要

一名37岁的日本男性在2001年被诊断为威尔逊病所致肝硬化，并接受了青霉胺治疗。此后，他因肝脏占位性病变入院接受进一步检查。该患者于2010年5月被诊断为肝细胞癌（HCC）（第7段，直径2.5 cm），并接受了射频消融治疗。非癌区域的活检结果显示为脂肪肝，未发现肝硬化结节。威尔逊病的长期治疗可能会改善肝纤维化，在这种情况下需要通过腹部影像学仔细筛查HCC。