Kumagi Teru, Horiike Norio, Abe Masanori, Kurose Kiyotaka, Iuchi Hideto, Masumoto Toshikazu, Joko Koji, Akbar Sk Fazle, Michitaka Kojiro, Onji Morikazu
Third Department of Internal Medicine, Ehime University School of Medicine, Japan.
Intern Med. 2005 May;44(5):439-43. doi: 10.2169/internalmedicine.44.439.
We report a 66-year-old male patient with hepatocellular carcinoma (HCC) associated with Wilson's disease. The patient presented with unresolving abnormal liver function test, decreased serum ceruloplasmin levels and increased 24-hour urine copper excretion. Liver biopsy specimen revealed the presence of increased levels of copper and features suggestive of Wilson's disease. Abdominal imaging showed the existence of a small HCC. Three years after chemoembolization and microwave coagulation therapy for HCC, he died of hepatic failure, which apparently resulted from chemoembolization. Patients with Wilson's disease should be screened for HCC. We should elude therapies such as chemoembolization in these patients.
我们报告一例66岁男性肝细胞癌（HCC）患者，其患有威尔逊病。该患者肝功能检查异常持续不缓解，血清铜蓝蛋白水平降低，24小时尿铜排泄增加。肝活检标本显示铜水平升高及提示威尔逊病的特征。腹部影像学检查发现一个小的HCC。对HCC进行化疗栓塞和微波凝固治疗三年后，他死于肝衰竭，显然是由化疗栓塞导致的。患有威尔逊病的患者应筛查HCC。我们应避免对这些患者进行化疗栓塞等治疗。
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