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铜中毒性小儿威尔逊氏病肝硬化与肝细胞癌:一例报告并文献复习

Beneath the Copper-Pediatric Wilson's Disease Cirrhosis and Hepatocellular Carcinoma: A Case Report with Literature Review.

作者信息

Rosencrantz Richard A, LeCompte Lesli, Yusuf Yasmin

机构信息

Department of Pediatrics, Section of Gastroenterology and Hepatobiliary Diseases, New York Medical College, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, New York.

Department of Radiology, New York Medical College, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, New York.

出版信息

Semin Liver Dis. 2015 Nov;35(4):434-8. doi: 10.1055/s-0035-1567828. Epub 2015 Dec 16.

Abstract

Primary hepatic malignancies are uncommon in pediatrics. Tumors such as hepatocellular carcinoma (HCC) develop typically in the setting of chronic liver disease. The incidence of HCC in Wilson's disease-related cirrhosis is disproportionately lower than in many other forms of end-stage liver disease. A preadolescent girl presented with Wilson's disease cirrhosis and a HCC requiring orthotopic liver transplantation. This case highlights the need to consider hepatic malignancies even in young Wilson's disease patients. Pediatric Wilson's disease and the hepatic tumor literature are reviewed.

摘要

原发性肝脏恶性肿瘤在儿科并不常见。诸如肝细胞癌(HCC)之类的肿瘤通常在慢性肝病的背景下发生。与威尔逊病相关的肝硬化中HCC的发病率比许多其他形式的终末期肝病要低得多。一名青春期前女孩患有威尔逊病肝硬化和需要原位肝移植的HCC。该病例凸显了即使是年轻的威尔逊病患者也需要考虑肝脏恶性肿瘤。本文对小儿威尔逊病及肝脏肿瘤文献进行了综述。

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引用本文的文献

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Wilson's Disease: An Update on the Diagnostic Workup and Management.
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