[The receptor binding of 3H-corticosterone and the dopamine content in the striatum of rats with a predisposition to audiogenic seizures].

The reactivity of hypophyseal-adrenocortical system, the receptor binding of 3H-corticosterone, and the catecholamines content in cerebral monoaminergic structures were studied in the Krushinskiĭ-Molodkina rats predisposed to audiogenic seizures and in control Wistar rats. No significant linear differences were found in these parameters in conditions of normal living activity. The hypophyseal-adrenocortical system of the Krushinskiĭ-Molodkina rats proved to be more responsive to auditory action. These animals revealed a higher dopamine content and a higher receptor binding of 3H-corticosterone in the striatum as compared with Wistar rats. The catecholamines and corticosteroids seem to interact in the process of regulation of the hypophyseal-adrenocortical system reactivity and of the function of nigrostriatal system when performing the organism response to a stimulus.