Kosacheva E S, Kudrin V S, Fedotova I B, Semiokhina A F, Raevskiĭ K S
Laboratory of Neurochemical Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Eksp Klin Farmakol. 1998 May-Jun;61(3):25-7.
It was shown that the content of serotonin (5-OT) and 5-oxyindoleacetic acid (5-OIAA) in the temporal cortex, hippocampus and medulla oblongata and the content of dopamine and 3,4-dihydroxyphenilacetic acid in the striatum are increased initially, while the level of norepinephrine in the striatum is reduced in Krushinskiĭ-Molodkina rats genetically predisposed to audiogenic epilepsy in comparison with Wistar rats. Carbamazepine levelled out the changes in the 5-OT and 5-OIAA levels at the peak of the audiogenic attack in the temporal cortex and hippocampus, causing at the same time a sum increase in the content of all monoamines and their metabolites in the medulla oblongata and striatum.
结果表明，与Wistar大鼠相比，在遗传上易患听源性癫痫的Krushinskiĭ-Molodkina大鼠的颞叶皮质、海马和延髓中血清素（5-羟色胺，5-OT）和5-羟吲哚乙酸（5-OIAA）的含量以及纹状体中多巴胺和3,4-二羟基苯乙酸的含量最初会增加，而纹状体中去甲肾上腺素水平则降低。卡马西平使颞叶皮质和海马听源性发作高峰期的5-OT和5-OIAA水平变化趋于平稳，同时导致延髓和纹状体中所有单胺及其代谢产物的含量总体增加。
