FPG Child Development Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
J Autism Dev Disord. 2012 Jun;42(6):937-46. doi: 10.1007/s10803-011-1316-8.
Aberrant attention is a core feature of fragile X syndrome (FXS), however, little is known regarding the developmental trajectory and underlying physiological processes of attention deficits in FXS. Atypical visual attention is an early emerging and robust indictor of autism in idiopathic (non-FXS) autism. Using a biobehavioral approach with gaze direction and heart activity, we examined visual attention in infants with FXS at 9, 12, and 18 months of age with a cross-sectional comparison to 12-month-old typically developing infants. Analyses revealed lower HR variability, shallower HR decelerations, and prolonged look durations in 12-month old infants with FXS compared to typical controls. Look duration and increased latency to disengage attention were correlated with severity of autistic behavior but not mental age.
注意力异常是脆性 X 综合征（FXS）的核心特征，但对于 FXS 中注意力缺陷的发展轨迹和潜在生理过程知之甚少。异常的视觉注意力是特发性（非 FXS）自闭症中自闭症的早期出现和强有力的指标。我们使用带有注视方向和心脏活动的生物行为方法，在 9、12 和 18 个月大时检查了 FXS 婴儿的视觉注意力，并与 12 个月大的正常发育婴儿进行了横断面比较。分析显示，与典型对照组相比，12 个月大的 FXS 婴儿的心率变异性较低，心率减速较浅，注视时间延长。注视时间和注意力分散潜伏期的增加与自闭症行为的严重程度相关，但与心理年龄无关。
