McDuffie Andrea, Thurman Angela John, Hagerman Randi J, Abbeduto Leonard
MIND Institute, University of California, Davis, 2825 50th Street, Room 2274, Sacramento, CA, 95817, USA,
J Autism Dev Disord. 2015 Jul;45(7):1925-37. doi: 10.1007/s10803-013-2013-6.
Symptoms of autism are frequent in males with fragile X syndrome (FXS), but it is not clear whether symptom profiles differ from those of nonsyndromic ASD. Using individual item scores from the Autism Diagnostic Inventory-Revised, we examined which current symptoms of autism differed in boys with FXS relative to same-aged boys diagnosed with nonsyndromic ASD. In addition, different subsamples of participants were matched on autism diagnostic status and severity of autism symptoms. Between-group comparisons revealed that boys with FXS showed significantly less impairment in Social Smiling than did age-, diagnostic-, and severity-matched boys with nonsyndromic ASD. Severity-matched boys with FXS showed more impairment in complex mannerisms than did boys with nonsyndromic ASD. Behavioral differences between FXS and nonsyndromic ASD may be of theoretical importance in understanding the causes and correlates of ASD in FXS and in developing and implementing appropriate treatments.
脆性X综合征（FXS）男性患者中自闭症症状很常见，但尚不清楚症状特征是否与非综合征性自闭症谱系障碍（ASD）不同。我们使用《自闭症诊断访谈量表修订版》的单项得分，研究了脆性X综合征男孩相对于被诊断为非综合征性ASD的同龄男孩，当前哪些自闭症症状存在差异。此外，在自闭症诊断状态和自闭症症状严重程度方面对不同的参与者子样本进行了匹配。组间比较显示，与年龄、诊断和严重程度匹配的非综合征性ASD男孩相比，脆性X综合征男孩在社交微笑方面的损害明显更小。与非综合征性ASD男孩相比，严重程度匹配的脆性X综合征男孩在复杂举止方面的损害更大。脆性X综合征和非综合征性ASD之间的行为差异对于理解脆性X综合征中ASD的病因及相关因素，以及开发和实施适当的治疗方法可能具有理论重要性。
