Ankara Ataturk Education and Research Hospital, Department of Pulmonary Medicine, Ankara, Turkey.
J Investig Allergol Clin Immunol. 2011;21(4):290-6.
It has been shown that the prevalence of asthma in obese people has increased in recent years. The aim of this study was to evaluate factors involved in the relationship between asthma and obesity in women,
We evaluated serum leptin levels, fractional exhaled nitric oxide (FE(N0), asthma control (using theAsthma Control Test [ACT]), and presence of atopy in 41 obese women with asthma and 40 non-obese women with asthma. We also compared the relationship between body mass index (BMI) and these parameters between the 2 groups.
Serum leptin levels were significantly higher in obese asthmatics than in nonobese asthmatics (P < .05). In the obese group, leptin levels were positively correlated with FE(O) levels (r = 0.439, P = .004). Uncontrolled asthma (ACT score <20) was detected in 61% of women in the obese group compared to just 38% of those in the nonobese group (P = -.035). In atopic patients, total immunoglobulin E levels were positively correlated with leptin levels (r = 0.329, P = .038). When the 81 women were classified according to asthma control, high BMI was found to be the only significant factor that contributed to poor asthma control.
We have shown that serum leptin levels might have a role in poor asthma control in obese patients, and can conclude that obesity is an important factor in uncontrolled asthma.
近年来，肥胖人群中哮喘的患病率有所增加。本研究旨在评估女性哮喘与肥胖之间关系中涉及的因素。
我们评估了 41 例肥胖哮喘女性和 40 例非肥胖哮喘女性的血清瘦素水平、呼出气中一氧化氮分数（FE（NO））、哮喘控制情况（采用哮喘控制测试[ACT]）和过敏情况。我们还比较了两组之间 BMI 与这些参数之间的关系。
肥胖哮喘患者的血清瘦素水平明显高于非肥胖哮喘患者（P<0.05）。在肥胖组中，瘦素水平与 FE（NO）水平呈正相关（r=0.439，P=0.004）。与非肥胖组相比，肥胖组中未得到控制的哮喘（ACT 评分<20）占 61%，而非肥胖组仅占 38%（P=0.035）。在过敏患者中，总免疫球蛋白 E 水平与瘦素水平呈正相关（r=0.329，P=0.038）。当根据哮喘控制情况对 81 名女性进行分类时，发现高 BMI 是导致哮喘控制不佳的唯一显著因素。
我们已经表明，血清瘦素水平可能在肥胖患者中对哮喘控制不佳有一定作用，并且可以得出结论，肥胖是哮喘控制不佳的一个重要因素。
