National Research Council of Italy, Institute of Biomedicine and Molecular Immunology, Palermo, Italy.
Ann Allergy Asthma Immunol. 2011 Oct;107(4):330-6. doi: 10.1016/j.anai.2011.08.001.
Increased body weight may influence airway inflammatory mechanisms.
To assess whether overweight-obesity (OW-O), evaluated as increased body mass index, is associated either with exhaled nitric oxide (eNO), a marker of airway inflammation, or with allergic sensitization in a large sample of children and adolescents.
A cross-sectional, epidemiological study was performed on a population sample of schoolchildren evaluating 708 subjects (age 10-16 years; BMI 13-39 kg/m(2)) by respiratory health questionnaire, skin prick tests, spirometry, and eNO measure.
Prevalence rates were: OW-O 16.4%, asthma ever (A) 11.9%, and rhinoconjunctivitis (RC) 14.8%. Asthma ever and allergic sensitization were significantly more frequent among OW-O (21.0 and 51.6%) than in non-OW-O (10.2 and 37.0%, respectively). The forced expiratory volume in 1 second (FEV(1))/forced vital capacity (FVC) ratio was not significantly different between OW-O and non-OW-O. Exhaled NO (median and interquartile range) was 15.3 (11.2-23.1) ppb in the overall sample, 20.3 (12.9-35.8) ppb among allergic subjects, and 13.9 (10.6-18.3) ppb among nonallergic subjects (P<.0001). No significant difference between OW-O and non OW-O subjects was found in eNO levels. Similarly, OW-O subjects with A or RC did not show significantly higher eNO levels than non-OW-O. In a logistic regression model, presence of allergic sensitization, A, and RC, and not OW-O, were significant predictors of increased eNO.
In children, OW-O was not associated with increased eNO levels, but it was an independent risk factor for asthma and allergic sensitization.
体重增加可能会影响气道炎症机制。
评估超重肥胖（OW-O），即体重指数增加，是否与大量儿童和青少年的呼出气一氧化氮（eNO），一种气道炎症标志物，或与过敏致敏有关。
对一组学龄儿童进行了一项横断面、流行病学研究，通过呼吸健康问卷、皮肤点刺试验、肺量计和 eNO 测量评估了 708 名受试者（年龄 10-16 岁；BMI 13-39 kg/m²）。
OW-O 的患病率为 16.4%，哮喘既往史（A）为 11.9%，鼻炎结膜炎（RC）为 14.8%。OW-O 中哮喘既往史和过敏致敏的发生率明显高于非 OW-O（分别为 21.0%和 51.6%）。OW-O 和非 OW-O 之间的 1 秒用力呼气量（FEV1）/用力肺活量（FVC）比值无显著差异。呼出气一氧化氮（eNO）（中位数和四分位间距）在整个样本中为 15.3（11.2-23.1）ppb，在过敏组中为 20.3（12.9-35.8）ppb，在非过敏组中为 13.9（10.6-18.3）ppb（P<.0001）。OW-O 和非 OW-O 受试者之间的 eNO 水平无显著差异。同样，OW-O 伴哮喘或 RC 的受试者的 eNO 水平也不比非 OW-O 受试者高。在逻辑回归模型中，过敏致敏、哮喘和 RC 的存在，而不是 OW-O，是 eNO 升高的显著预测因子。
在儿童中，OW-O 与 eNO 水平升高无关，但 OW-O 是哮喘和过敏致敏的独立危险因素。
