Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA.
J Biomed Opt. 2011 Jun;16(6):066001. doi: 10.1117/1.3587631.
The design and testing of a pneumatic optical positioning interface produced with the goal of improving fiber positioning in magnetic resonance (MR)-guided diffuse spectral imaging of breast cancer is presented. The system was created for vertical positioning of optical fibers inside the MR bore during a patient exam to target suspicious lesions with MR scans for reference and collect multiple planes of optical data. The interface includes new fiber plates for mechanical and optical coupling to the breast, and was tested in phantoms and human imaging. Reconstructions with data taken in the new interface show acceptable linearity over different absorber concentrations (residual norm = 0.067), and exhibit good contrast recovery at different imaging planes, which is consistent with previous work. An example of human breast imaging through the new interface is shown and a discussion of how it compares to other patient interfaces for breast imaging is presented. Design goals of increasing the available degrees of freedom for fiber positioning while maintaining good patient-fiber contact and comfort were accomplished. This interface allows improved volumetric imaging with interactive and accurate slice selection to quantify targeted suspicious lesions.
本文提出了一种气动光学定位接口的设计和测试，旨在改善磁共振（MR）引导漫谱乳腺癌成像中光纤的定位。该系统是为了在患者检查期间在 MR 孔内垂直定位光纤而创建的，以便用 MR 扫描对可疑病变进行定位参考，并收集多个平面的光学数据。该接口包括用于与乳房进行机械和光学耦合的新型光纤板，并在体模和人体成像中进行了测试。在新接口中采集的数据进行重建后，在不同的吸收剂浓度下表现出可接受的线性度（残余范数 = 0.067），并且在不同的成像平面上表现出良好的对比度恢复，这与之前的工作一致。展示了通过新接口进行的人体乳房成像的示例，并讨论了它与其他用于乳房成像的患者接口相比的优缺点。该接口通过保持良好的患者-光纤接触和舒适性，增加了光纤定位的自由度，从而实现了改进的容积成像，能够进行交互式和准确的切片选择，以量化目标可疑病变。
