Dartmouth College, Thayer School of Engineering, Hanover, NH 03755, USA.
J Biomed Opt. 2014 Jan;19(1):011010. doi: 10.1117/1.JBO.19.1.011010.
A new optical parallel detection system of hybrid frequency and continuous-wave domains was developed to improve the data quality and accuracy in recovery of all breast optical properties. This new system was deployed in a previously existing system for magnetic resonance imaging (MRI)-guided spectroscopy, and allows incorporation of additional near-infrared wavelengths beyond 850 nm, with interlaced channels of photomultiplier tubes (PMTs) and silicon photodiodes (PDs). The acquisition time for obtaining frequency-domain data at six wavelengths (660, 735, 785, 808, 826, and 849 nm) and continuous-wave data at three wavelengths (903, 912, and 948 nm) is 12 min. The dynamic ranges of the detected signal are 105 and 106 for PMT and PD detectors, respectively. Compared to the previous detection system, the SNR ratio of frequency-domain detection was improved by nearly 103 through the addition of an RF amplifier and the utilization of programmable gain. The current system is being utilized in a clinical trial imaging suspected breast cancer tumors as detected by contrast MRI scans.
一种新的光频域和连续波域混合并行检测系统被开发出来，以提高恢复所有乳房光学特性时的数据质量和准确性。该系统被部署在一个现有的磁共振成像（MRI）引导光谱系统中，并允许在 850nm 以上的近红外波长范围内增加额外的波长，同时交错排列光电倍增管（PMT）和硅光电二极管（PD）通道。在六个波长（660、735、785、808、826 和 849nm）获取频域数据和三个波长（903、912 和 948nm）连续波数据的采集时间为 12 分钟。PMT 和 PD 探测器的检测信号的动态范围分别为 105 和 106。与以前的检测系统相比，通过增加射频放大器和可编程增益，频域检测的信噪比提高了近 103。目前，该系统正在一项临床试验中被用于成像怀疑有乳腺癌的肿瘤，这些肿瘤是通过对比 MRI 扫描检测到的。
